E-Dissertationen: Search
Now showing items 31-40 of 71
Aptamer-mediated transactivation of transcription utilizing CRISPR/Cas9 and a photoreceptor
(2021-12-16)
In synthetic biology, spatio-temporal control of molecular functions is an essential tool for the investigation and manipulation of cellular processes. The usage of light enables a reversible non-invasive trigger, that ...
Evolution of DNA methylation in insects
(2021-05-21)
DNA methylation, the addition of a methyl group (-CH3) to a genomic cytosine by a DNA methyltransferase, is the most thoroughly studied epigenetic modification across eukaryotes. Functionally, it is associated with the ...
Die biologische Funktion der N1-2´O-Methylierung eukaryotischer mRNA durch die Methyltransferase CMTr1
(2021-05-14)
Eukaryoten modifizieren das 5´-Ende ihrer mRNA mit einem invertierten N7-methyliertem Guanosin (m7G). Diese Cap0 genannte Struktur wird in höheren Eukaryoten durch die Methyltransferase CMTr1 weiter modifiziert: CMTr1 ...
Entwicklung eines in vitro Testsystems zur Identifizierung pflanzlicher Signale für Mehltau (Blumeria graminis) an Weizen (Triticum aestivum)
(2021-02-11)
Blumeria graminis ist der Erreger des Echten Mehltaus an Weizen (Triticum aestivum), einer der wichtigsten Kulturpflanzen weltweit. Durch diese Pflanzenkrankheit können hohe Ernteverluste verursacht werden. Die Keimung und ......
Development of an in vitro test system to identify plant signals for powdery mildew (Blumeria graminis) on wheat (Triticum aestivum
Blumeria graminis is the causal agent of powdery mildew on wheat ......
Development of an in vitro test system to identify plant signals for powdery mildew (Blumeria graminis) on wheat (Triticum aestivum
Blumeria graminis is the causal agent of powdery mildew on wheat ......
Antiapoptotic survival strategies of human neurons
(2021-06-28)
Neurons of the central and peripheral nervous system are the key information processing and relay units within the human body. Since neurons are post-mitotic cells and neurogenesis in the adult human brain is very limited, ...
Charakterisierung zellulärer Kräfte von Mikrogeweben durch Entwicklung eines elastischen, dreidimensionalen Zellkultursystems
(2021-03-12)
Zellen sind in einem Organismus eng mit der Extrazellulären Matrix (ECM) verbunden. Die mechanischen Eigenschaften der ECM, wie die Elastizität sowie ihre Topographie sind dabei besonders entscheidend für Epithelzellen. ...
A reporter cell system for TREM2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region
(2021-06-08)
The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on myeloid-derived cell types. The extracellular immunoglobulin-like domain of TREM2 binds anionic ligands including Apolipoprotein ...
The Role of Phytol Degradation in Chlorophyll and Tocopherol (Vitamin E) Metabolism
(2021-10-14)
The phytol degradation in the model plant Arabidopsis thaliana was studied. Phytol is the hydrophobic side of chlorophyll and is considered to be most abundant isoprenoid molecule in the biosphere. But the degradation of ...
Mechanisms of epileptogenesis in animal models of developmental brain lesions
(2021-11-05)
Developmental brain lesions, including glioneuronal tumors (GNT) and malformations of cortical development (MCD), are among the most common causes for pharmaco-resistant epilepsy. Despite substantial differences, their ...
Evolution of the Activity Cliff Concept and Practical Implications for Compound Design
(2021-07-22)
Entering the “big data” era, a number of different research areas have witnessed an enormous increase in data at an exponential rate. For drug discovery, various publicly available protein structure and compound bioactivity ...