E-Dissertationen: Search
Now showing items 51-60 of 71
Hippocampal network and inhibitory neuron dysfunction in age and disease
(2021-10-25)
Aging and Alzheimer’s disease (AD) are two highly intertwined pathological processes. Indeed, one of the highest risk factors for developing AD is age. Mechanistically, it has been suggested that remodeling of inhibitory ......
Inhibitory Circuits of the CA3-Dentate Gyrus System
(2021-11-04)
Neuronal inhibition is an essential feature of all brain areas. Besides controlling the average rate of neuronal firing, it also controls the precise timing of action potentials and mediates several types of network ...
Role of presenilins in autophagy and growth factor signaling
(2021-02-08)
Alzheimer's disease is the most common neurodegenerative disease and affects millions of people worldwide. To date, no efficient therapies are known for a cure. As people suffering from diabetes mellitus type 2 have an ...
OptoRiboGenetics: Post-transcriptional control of gene expression by light
(2021-08-26)
Gene expression is tightly regulated in mammalian cells at the post transcriptional level and its precise manipulation has proven to be valuable for protein overexpression and gene therapy. Implementation of light-responsive ......
OptoRiboGenetics - Posttranskriptionelle Kontrolle der Genexpression mit Licht
Die Genexpression von Säugetierzellen wird maßgeblich auf post-transkriptioneller Ebene reguliert und das Eingreifen auf ......
OptoRiboGenetics - Posttranskriptionelle Kontrolle der Genexpression mit Licht
Die Genexpression von Säugetierzellen wird maßgeblich auf post-transkriptioneller Ebene reguliert und das Eingreifen auf ......
Investigations into side chain assembly and attachment during biosynthesis of the G protein inhibitor FR900359
(2021-06-07)
The natural product FR900359 (FR) selectively inhibits Gaq proteins and thus intracellular signalling of many G protein-coupled receptors. This unique mechanism of action makes FR an indispensable pharmacological tool to ......
The Role of microRNAs in the Regulation of Human UDP-glucuronosyltransferases (UGTs)
(2021-06-14)
The liver is involved in endo- and xenobiotic metabolism due to the expression of drug-metabolizing UDP-glucuronosyltransferases (UGTs). By UGT-mediated elimination of hazardous compounds and other reactive metabolites, ...
Implementation and characterisation of click-SELEX targeting the chemokine CXCL9, for the development of a POC device for renal allograft rejection
(2021-11-04)
Renal allograft rejection is a serious medicinal condition, as appr. 25 % of the allografts are rejected. This medical disorder will lead to death of the patient if not treated early. Currently the gold standard to diagnose ...
Optimierung der mikrobiellen Produktion von präbiotischen Zuckerderivaten auf Levan-Basis
(2021-04-21)
Die vorliegende Arbeit befasste sich mit der Entwicklung und Optimierung einer mikrobiellen Produktionsstrategie zur Synthese ß-2,6-glykosidisch verknüpfter Fruktane. Levan (ß-2,6-glykosidisch verknüpftes Fruktan) und ......
Generation of an RNA sensor to probe glycolysis in living cells via the key metabolite fructose 1,6-bisphosphate
(2021-06-24)
Glycolysis is the cornerstone of cell metabolism and is one of the oldest biochemical pathways known to life. Yet, methods to study glycolysis in single living cells are lacking. The glycolytic intermediate Fructose ...
Deciphering the functional role of the LIS1/NDEL1/14.3.3ε protein complex in the expansion of human cortical progenitors in an iPSC-derived organoid model
(2021-07-19)
The human brain is an exceptionally complex organ, both structurally and functionally, and represents the most remarkable progress in evolution. The human cortex is a highly organised and extensively folded structure ...