E-Dissertationen: Suche
Anzeige der Dokumente 11-19 von 19
Functional characterization of Cytoplasmic Polyadenylation Element Binding proteins in the developing and diseased brain
(2016-12-22)
Gliomas are the most common primary brain tumors with aggressive progression and devastating prognosis. Therefore identification of new therapeutic and diagnostic factors is necessary to improve the dramatic situation of ...
Click-SELEX: A versatile approach towards nucleobase-modified aptamers
(2016-11-28)
Aptamers are short nucleic acids that can be selected to bind specifically and with high affinity to a variety of targets, including small organic molecules and proteins. However, for a multitude of targets, traditional ...
Identification of protective immune responses and the immunomodulatory capacity of Litomosoides sigmodontis
(2016-11-29)
Using the mouse model Litomosoides sigmodontis, research focusing on the protective immune responses within the host as well as the immunomodulatory capabilities of filarial infections is possible. The immunomodulatory ......
Structural and Functional Characterization of Neurotoxic Oligomers of Pro-aggregant Tau Repeat Domain: A model for Tauopathy disease
(2016-04-26)
Tau protein is a microtubule associated protein present abundantly in the neurons of the central nervous system where it stabilizes the axonal microtubules thereby providing structural architecture for the axons of neurons. ...
Entwicklung neuer Therapiekonzepte im myxoiden Liposarkom: Die Rolle von Fibroblastenwachstumsfaktor-Rezeptoren und microRNAs
(2016-04-21)
Myxoide Liposarkome gehören zu den häufigsten Weichgewebssarkomen. Ihre Pathogenese ist aber bislang nur unvollständig verstanden und es stehen keine zielgerichteten Therapien zur Verfügung. Die für myxoide Liposarkome ...
Proteomische Funktionsanalyse humanbiologischer Systeme mittels chemisch modifizierter Proteine
(2016-04-18)
Das humane Proteom unterliegt gegenüber dem eher statischen Genom einem kontinuierlichen Auf- und Abbau. Diese Dynamik zeigt sich durch ein mehrschichtiges Muster an Protein-Protein Interaktionen.
Im ersten Teil ...
Im ersten Teil ...
Neuroprotective Effects of Polysialic Acid and SIGLEC-11 in Activated Phagocytic Cells
(2016-03-30)
SIGLEC-11 is an inhibitory receptor expressed on microglial cells and macrophages and can recognize α 2→8 linked Sias structures. The surface of neuron is decorated by different lengths of polySias. PolySia-SIGLEC-11 ...
Eine neue Helfer-Funktion von T Helfer 1 Zellen bei der Induktion von CD8+ T Zellen durch sinusoidale Endothelzellen der Leber
(2016-03-17)
Die sinusoidalen Endothelzellen der Leber (LSEC) nehmen kontinuierlich zirkulierende Antigene auf und kreuzpräsentieren diese CD8+ und CD4+ T Zellen. Unter homöostatischen Bedingungen leiten LSEC die Differenzierung ...
Augmin complex components control branching of sensory neuron dendrites in Drosophila larvae
(2016-02-05)
Microtubule is the major architectural element to support proper neuronal structure. It is tightly organized with intrinsic polarity and affects not only neuronal morphology but also the transport property within the cell. ......