E-Dissertationen: Search
Now showing items 31-40 of 109
Exploration of bioresources enables detection and characterization of natural products with antibacterial activities and elucidation of the corresponding biosyntheses for derivative generation
(2021-11-17)
The discovery of antibiotics in the early 20th century sparked a medicinal revolution, which for the first time in history enabled humankind to effectively combat bacterial infections. Despite this immense success, the ...
Functional impact of Kir4.1 channels in hippocampal NG2 glia on neuronal plasticity and behavior
(2020-08-25)
NG2 glia represents the 4th type of CNS glial cells. In white matter, most of them differentiate into myelinating oligodendrocytes but in grey matter a majority retains their NG2 phenotype throughout life. Intriguingly, ...
Aptamer-mediated transactivation of transcription utilizing CRISPR/Cas9 and a photoreceptor
(2021-12-16)
In synthetic biology, spatio-temporal control of molecular functions is an essential tool for the investigation and manipulation of cellular processes. The usage of light enables a reversible non-invasive trigger, that ...
Investigation of the procoagulant role of labile heme under hemolytic conditions
(2021-07-19)
Severe intravascular hemolysis leads to the excessive release of labile heme into the vascular compartment, thereby overwhelming the heme-binding capacity of the protective heme- scavenging system. As a consequence, labile ...
Toward a precision medicine in Alzheimer’s Disease: blood phenomic fingerprint for diagnostic and therapeutic developments
(2020-05-05)
There is an unmet clinical need to identify reliable blood biomarkers for Alzheimer’s Disease (AD) that can be used for diagnostics and therapeutic purposes.
The complex nature of AD, single-readout approaches ......
The complex nature of AD, single-readout approaches ......
Einfluss von Maßnahmen zur Verbesserung der Arzneimitteltherapiesicherheit im Krankenhaus auf die Inzidenz vermeidbarer unerwünschter Arzneimittelwirkungen bei älteren Patienten
(2022-08-31)
Zur Erhöhung der Arzneimitteltherapiesicherheit (AMTS) stehen heutzutage verschiedene Interventionen zur Verfügung. So sollte im Rahmen des High-5s-Projekts der WHO Medication Reconciliation erstmals an deutschen Krankenhäusern ...
Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
(2020-02-07)
The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a ......
Die biologische Funktion der N1-2´O-Methylierung eukaryotischer mRNA durch die Methyltransferase CMTr1
(2021-05-14)
Eukaryoten modifizieren das 5´-Ende ihrer mRNA mit einem invertierten N7-methyliertem Guanosin (m7G). Diese Cap0 genannte Struktur wird in höheren Eukaryoten durch die Methyltransferase CMTr1 weiter modifiziert: CMTr1 ...
Investigations on centrosomes, their function and regulation during immune synapse formation
(2022-01-24)
The centrosome is a cellular organelle well known for its function during cell division. It consists of two centrioles that are formed by microtubules and surrounded by a multiprotein matrix the so-called pericentriolar ...
Chemoinformatics-Driven Approaches for Kinase Drug Discovery
(2020-01-07)
Given their importance for the majority of cell physiology processes, protein kinases are among the most extensively studied protein targets in drug discovery. Inappropriate regulation of their basal levels results in ...