E-Dissertationen: Suche
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Functional in vivo calcium imaging in the hippocampus under healthy and disease conditions
(2020-04-22)
The hippocampus has long been known to be essential for all features of memory processing. Hippocampal function strongly depends on the orchestrated activity of transiently autonomous neuronal populations that create the ......
Creld1 controls T cell homeostasis in mouse and human
(2020-07-07)
Cysteine-rich with EGF-like domains 1 (Creld1) was recently found to be fundamental for the VEGF-mediated activation of NFATc1 during heart development. Creld1 complete KO in mice is lethal due to developmental problems ...
Synthesis and characterisation of novel isoform-selective histone deacetylase inhibitors (HDACi) and HDACi-based multi-target ligands
(2022-04-26)
In the quickly evolving field of epigenetic therapy, histone deacetylases (HDACs) have emerged as preferred targets for the treatment of cancer and other conditions such as viral infections, neurodegenerative disorders, ...
Einfluss der zellspezifischen Deletion des miR-17~92-Clusters auf die Entwicklung des Kleinhirns
(2022-06-28)
Seit der Entdeckung der ersten micro-Ribonukleinsäure (miRNA/miR) wurde intensiv an der Funktion von miRNAs bei der Entwicklung des Kleinhirns geforscht. Dennoch sind die Mechanismen, über die miRNAs die beteiligten ...
Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy
(2022-07-07)
Memory deficits are one of the most debilitating and common symptoms of temporal lobe epilepsy. However, so far, little is known about mechanisms underlying cognitive deficits and how pharmacologically target them. In most ...
A light-dependent aptamer-photoreceptor system enables spatiotemporal control of RNA biochemistry
(2022-07-29)
Light plays an important role in all kingdoms of life and regulates processes such as plant growth, flowering or vision in complex life forms. The growing field of optogenetics harnesses those properties by combining them ...
Pharmacometric modeling of fluoropyrimidines
(2023-03-07)
The fluoropyrimidine drugs fluorouracil (5FU) and capecitabine are widely used for the treatment of various solid tumors. Despite the long-term clinical experience with these drugs a substantial proportion of patients is ...
Understanding the systemic immune response in COVID-19 – one cell at a time
(2023-07-03)
(noch nicht zugänglich / not yet accessible)
Untersuchungen zur Wirkungsweise von Cervimycin
(2023-06-22)
(noch nicht zugänglich / not yet accessible)
Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84
(2021-06-21)
G protein-coupled receptors (GPCRs) are ideal drug targets. Their characteristic tissue distribution, marked ligand specificity, and their roles in countless (patho)physiological processes are being exploited by more than ...