E-Dissertationen: Suche
Anzeige der Dokumente 151-160 von 255
Potential of Complementary Methods for the Authentication of Herbal Substances and their Mixtures
(2015-10-22)
Herbal substances and preparations thereof play an important role in healthcare systems worldwide. An essential prerequisite for the safe and effective use of herbal medicines is the unequivocal identification of the plant ...
Oxytocin – the prosocial molecule?: Intranasal oxytocin effects on social approach behavior, social cognition, volitional and emotional ambivalence in healthy human beings
(2015-10-30)
Oxytocin (OXT) is a highly conserved neuropeptide, regarding both its chemical structure and its functionality. It has been traced back at least 700 million years. OXT’s fundamental role lies in reproduction and parenting ...
Chemical modifications of DNA activate the cGAS/STING-signaling pathway even in the presence of the cytosolic exonuclease TREX1
(2015-09-16)
To recognize pathogen threats, the innate immune system is equipped with pattern recognition receptors (PRRs) that bind to and are activated by pathogen-associated molecular patterns (PAMPs). Most PAMPs are conserved across ...
Immune modulation by experimental filarial infection and its impact on E. coli-induced sepsis
(2015-11-12)
Helminths cause so-called neglected tropical diseases in tropical and sub-tropical regions and are prevalent in almost one third of mankind. Thus, co-infections of helminths with other pathogens are common. However, the ......
Structural and Functional Characterization of Neurotoxic Oligomers of Pro-aggregant Tau Repeat Domain: A model for Tauopathy disease
(2016-04-26)
Tau protein is a microtubule associated protein present abundantly in the neurons of the central nervous system where it stabilizes the axonal microtubules thereby providing structural architecture for the axons of neurons. ...
Entwicklung neuer Therapiekonzepte im myxoiden Liposarkom: Die Rolle von Fibroblastenwachstumsfaktor-Rezeptoren und microRNAs
(2016-04-21)
Myxoide Liposarkome gehören zu den häufigsten Weichgewebssarkomen. Ihre Pathogenese ist aber bislang nur unvollständig verstanden und es stehen keine zielgerichteten Therapien zur Verfügung. Die für myxoide Liposarkome ...
Proteomische Funktionsanalyse humanbiologischer Systeme mittels chemisch modifizierter Proteine
(2016-04-18)
Das humane Proteom unterliegt gegenüber dem eher statischen Genom einem kontinuierlichen Auf- und Abbau. Diese Dynamik zeigt sich durch ein mehrschichtiges Muster an Protein-Protein Interaktionen.
Im ersten Teil ...
Im ersten Teil ...
The role of the Hippo pathway in etiology and progression of pancreato-biliary tumors and clear cell renal cell carcinoma
(2016-01-21)
In the quest for the discovery of novel targets for cancer therapy, aberrantly reactivated embryonic signaling pathways have proven to be a rich mine and recent years have seen the introduction of the hedgehog-inhibitor ...
Neuroprotective Effects of Polysialic Acid and SIGLEC-11 in Activated Phagocytic Cells
(2016-03-30)
SIGLEC-11 is an inhibitory receptor expressed on microglial cells and macrophages and can recognize α 2→8 linked Sias structures. The surface of neuron is decorated by different lengths of polySias. PolySia-SIGLEC-11 ...
Eine neue Helfer-Funktion von T Helfer 1 Zellen bei der Induktion von CD8+ T Zellen durch sinusoidale Endothelzellen der Leber
(2016-03-17)
Die sinusoidalen Endothelzellen der Leber (LSEC) nehmen kontinuierlich zirkulierende Antigene auf und kreuzpräsentieren diese CD8+ und CD4+ T Zellen. Unter homöostatischen Bedingungen leiten LSEC die Differenzierung ...