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Investigations on the structure, biosynthesis and biology of antibacterial cyclic lipopeptides
(2013-03-21)
The study was aimed to find new antibacterial cyclic lipopeptides in Pseudomonas bacteria using genome mining techniques. Application of this genome-driven approach led to the in-silico identification of ...
Immune Regulation in Human Filariasis
(2013-03-14)
Vector transmitted diseases such as the tropical helminth infections onchocerciasis and lymphatic filariasis (LF) affect more than 150 million people worldwide and are both considered major public health concerns. In order ...
Pattern Recognition Receptor and Vaccination Studies in the Murine Model of Lymphatic Filariasis
(2013-03-06)
Lymphatic filariasis is a parasitic helminth infection that affects approximately 120 million people. About one third of the infected individuals develop pathological manifestations, e.g. lymphedema. Causative agents of ......
Notwendigkeit klinischer Prüfungen bei technischen Änderungen an der Applikationseinheit von Inhalationsprodukten
(2013-02-15)
Inhalationsprodukte besitzen eine Sonderstellung unter den Arzneimitteln, weil ihr therapeutisches Profil in entscheidendem Maß von einem Bestandteil des Behältnisverschlusssystems, der Applikationseinheit, beeinflusst ...
Numerische Simulation von Knochenumbauvorgängen um zahnärztliche Implantate mit der Finite-Elemente-Methode
(2013-01-23)
Zur Untersuchung der Knochenumbauvorgänge sind neben klinischen auch biomechanische Methoden, die den Hauptgegenstand der vorliegenden Arbeit bilden, von besonderer Bedeutung. Insbesondere numerische Simulationen der ...
Biosynthesis of Phenylnannolone A, a MDR Reversal Agent from Nannocystis pusilla
(2013-02-27)
Myxobacteria are gliding bacteria known to produce an immense diverse spectrum of natural products with unique modes of action. Nannocystis pusilla B150 is a myxobacterial representative, which is able to synthesize ......
Rapid astrocyte morphology changes during epileptogenesis in the rodent hippocampus
(2017-05-15)
In the past decades astrocytes have been demonstrated to play an important role in physiological brain processes but also neurodegenrative diseases. Their characteristic morphology allows them to closely contact neurons. ...
Unravelling mechanisms causing astrocytic uncoupling in epilepsy
(2017-10-06)
The dynamic regulation of connexins throughout its life cycle has profound impact on the level of gap junctional coupling in astrocytes. Astrocytic uncoupling in epilepsy can be viewed in the context of modifications in ...
Organization and function of signaling molecules in sperm
(2017-09-15)
Successful fertilization depends on the ability of sperm to locate the egg. Sperm from different species rely on diverse signaling components to gather chemical and physical cues and transduce them into a behavioral swimming ......
Um die Eizelle zu befruchten, müssen die Spermien die Eizelle zunächst lokalisieren. Dabei helfen ihnen unterschiedliche chemische oder physikalische Signale auf dem Weg zur Eizelle, die dann das Schwimmverhalten der ......
Um die Eizelle zu befruchten, müssen die Spermien die Eizelle zunächst lokalisieren. Dabei helfen ihnen unterschiedliche chemische oder physikalische Signale auf dem Weg zur Eizelle, die dann das Schwimmverhalten der ......
Wastewater-Irrigated Urban Agriculture in the Context of WASH in Ahmedabad, India: the impact of irrigation water quality on the incidence of diarrhea
(2017-03-29)
Introduction: Urban agriculture is a low-input system, where the inputs of production are drawn from the urban wastestream. The use of wastewater is beneficial, providing perennial irrigation water and reducing the need ...