E-Dissertationen: Search
Now showing items 161-170 of 215
Charakterisierung von PQQ-abhängigen Dehydrogenasen aus Sphingomonas wittichii RW1 und Entwicklung eines enzymatischen Verfahrens für die Quantifizierung von PQQ
(2015-11-05)
Die Entschlüsselung des Genoms von S. wittichii RW1 eröffnete die Möglichkeit neuartige PQQ-abhängige Dehydrogenasen zu entdecken. Es wurden alle potentiellen Chinoproteine aus S. wittichii RW1 bioinformatisch identifiziert. ......
Development and Interpretation of Machine Learning Models for Drug Discovery
(2015-11-19)
In drug discovery, domain experts from different fields such as medicinal chemistry, biology, and computer science often collaborate to develop novel pharmaceutical agents. Computational models developed in this process ...
Gene targeting in human pluripotent cell-derived neural stem cells for the study and treatment of neurological disorders
(2015-11-19)
Modern stem cell technology has made remarkable progress in recent years with the discovery of induced pluripotency, enabling the production of any cell type from any person in unlimited quantities, as well as improved ...
Tools for Reasoning about Effectful Declarative Programs
(2015-10-30)
In the pure functional language Haskell, nearly all side-effects that a function can produce have to be noted in its type. This includes input/output, propagation of a state, and nondeterminism. If no side-effects are ...
Synthese und Charakterisierung von mehrkernigen supramolekularen Koordinationsverbindungen
(2015-11-05)
Ziel dieser Arbeit war die Synthese neuer metallosupramolekularer Aggregate. So sollten neue Strukturmotive für die Bildung von Helicaten etabliert und die Bedingungen zur Bildung metallosupramolekularer Rauten systematisch, ...
Computational Methods for Structure-Activity Relationship Analysis and Activity Prediction
(2015-11-05)
Structure-activity relationship (SAR) analysis of small bioactive compounds is a key task in medicinal chemistry. Traditionally, SARs were established on a case-by-case basis. However, with the arrival of high-throughput ...
Filarial infection and filarial antigen administration promotes glucose tolerance in diet-induced obese mice
(2015-11-06)
Excess of energy intake combined with reduced physical activity leads to accumulation and expansion of adipose tissue. Imbalance between adipose tissue expansion and oxygenation during a high fat diet results in adipocytes ...
Changes of inhibitory micronetworks in the epileptic hippocampus and their response to anticonvulsant drugs
(2015-11-12)
With around 50 million people worldwide suffering from chronic epilepsy, it is one of the most common neurological disorders. However, despite extensive research in this area, the actual network mechanisms involved in the ...
Germyliden- und Germylidin-Komplexe des Molybdäns
(2015-01-09)
In den letzten zwei Jahrzehnten hat sich rund um Übergangsmetallkomplexe, die eine Dreifachbindung zu einem der schweren Homologen des Kohlenstoffs (Si–Pb) enthalten, ein neues Forschungsgebiet an der Grenzfläche zwischen ...
Chemische und molekularbiologische Studien am Psymberin-Gencluster
(2015-01-06)
Polyketide sind Naturstoffe und werden in Organismen von Polyketidsynthasen (PKS) gebildet. Der Mechanismus der Kettenverlängerung bei der Polyketidbildung ist eine Claisen-artige Kondensation von Acylbausteinen, durch die ......