E-Dissertationen: Search
Now showing items 61-70 of 71
Phylogeny and evolution of Adephaga and Neuropterida (Insecta: Holometabola) as inferred from analyses of next-generation sequencing data
(2021-09-17)
Knowing the evolutionary relationships of species is fundamental for comparative studies in biology as well as for biodiversity conservation. The main topic of this thesis is the investigation of phylogenetic relationships ...
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
Concepts of Immune Regulation in Chronic Filarial Infections
(2021-04-21)
Despite worldwide efforts to reduce filariasis, over 100 million individuals still suffer from filarial infections. Filarial infections continue to be a substantial drain at both economic and health levels, especially in ......
Electrostatic anchoring of SNAP25 to the plasma membrane
(2021-07-21)
Neurotransmission is based on incredibly rapid membrane trafficking cycles, mediating the release of neurotransmitters. The fusion machinery of the well-studied SNARE protein complex ensures the speed and precision of ...
Bridging between data and knowledge: New ways to better understand Alzheimer's Disease and Type 2 Diabetes comorbidity
(2021-06-15)
The holistic understanding of biological phenomena enabled by systems biology forms the basis of current research. As opposed to the principle of classical biology where behavior of a biological system is explained by ...
Odor-evoked modulation of the olfactory bulb by projections from the horizontal limb of the diagonal band of Broca
(2021-07-09)
Olfactory input encodes essential information about the environment and shapes adapted behavioral reactions. Hence, the olfactory system is complex with diverse brain areas processing the sensory input on different levels. ...
The interplay of differentially γ-carboxylated vitamin K dependent proteins constitute variable VKCFD1 phenotypes
(2021-11-18)
Vitamin K dependent coagulation factor deficiency type 1 (VKCFD1) is a rare hereditary bleeding disorder caused by mutations in γ-Glutamyl carboxylase (GGCX). VKCFD1 patients are treated with high dose of vitamin K, ...
Detection of Legionella pneumophila and Pseudomonas aeruginosa and biofilm experiments in four different cooling towers (construction and biocide treatment) and evaluation of IDEXX most probable number methods in industrial water samples
(2021-11-30)
The responsible maintenance of evaporative cooling systems is an essential element in reducing the risk of the environmental dispersion of legionellae and Legionnaires’ disease outbreaks. In Germany, the 42nd Ordinance ......
Translatome analysis and in vivo Ca2+ imaging of astrocytes in an Alzheimer’s disease mouse model
(2021-03-18)
One of the most prominent hallmarks of Alzheimer’s Disease (AD) is the accumulation of amyloid beta (Abeta) species, which have the tendency to form extracellular insoluble Abeta plaques and induce reactive astrogliosis ...
Regulation of inflammasome activation: roles for phospholipase C and mitochondria
(2021-08-05)
Inflammasomes are protein complexes serving as activation platforms for the protease caspase-1, which leads to a pro-inflammatory type of cell death termed pyroptosis and to maturation and release of the cytokines interleukin- ......