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Evaluating onco-geriatric scores and medication risks to improve cancer care for older patients
(2020-03-19)
The cancer therapy of older patients is challenging, being more complex than the therapy of younger patients. Older cancer patients show a higher toxicity risk during therapy and drug-related problems are common. In order ...
Characterisation of the unknown gene and the corresponding protein At3g29075 in Arabidopsis thaliana
(2020-04-01)
Phospholipases D (PLDs) are involved in different plant stress responses, exclusively to abiotic stresses like cold, salinity, and drought. The PLD enzymes catalyse the hydrolysis of membrane phospholipids into phosphatidic ......
Analyzing the impact of astrocyte-oligodendrocyte gap junction coupling on neuronal activity in the thalamus
(2020-04-01)
Glia is now recognized as a key element in brain metabolism. In the thalamus, astrocytes and oligodendrocytes are coupled via gap junction channels and form extensive panglial networks. Interestingly and in contrast to ...
Molecular Mechanisms of NLRP3 Inflammasome Activation: Involvement of the Leucine-Rich Repeat Domain and Charcot-Leyden Crystals
(2021-07-29)
Chronic inflammation is a major driver of several non-communicable diseases. The cytosolic pattern recognition receptor NLRP3 is involved in the development of many of these diseases, as its activation in innate immune ...
Pharmacological reprogramming of macrophages through aptamiRs
(2020-03-05)
Nucleic acid-based molecules have certain advantages over conventional drugs or protein-based target approaches. Chemically synthetized nucleic acids-based molecules are known as aptamers. They are selected from a combinatorial ...
Molecular and biochemical studies of the Craterostigma plantagineum cell wall during dehydration and rehydration
(2020-02-17)
Craterostigma plantagineum belongs to the desiccation tolerant angiosperm plants. Upon dehydration leaves fold and the cells shrink which is reversed during rehydration. To understand this process changes in cell wall ......
Recognition of cytosolic 3´P DNA & The role of GCET2+ DCs in cross-presentation
(2020-04-01)
In mammalian cells, DNA is confined to the nucleus and mitochondria. Detection of DNA in other compartments like the cytoplasm indicates danger and infection. Our research group has previously discovered that 3´monophosphate ...
Biochemical and structural characterization of the NLRP3 inflammasome
(2020-02-13)
The innate immune system utilizes inflammasome proteins to recognize danger signals and to fight invading pathogens. To date, the most studied inflammasome protein is NLRP3 - a multidomain protein, composed of a N-terminal ...
Characterization of Ceramide synthase 2 dysfunctions caused by targeted mutations in transgenic mice
(2020-02-10)
Ceramide species are the precursor of sphingolipids, which serve as structural components of biological membranes or are bioactive molecules. In mammals, ceramides are synthesised by a family of ceramide synthases (CerS) ......