E-Dissertationen: Suche
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Amyloid β-peptide-induced progressive neurodegeneration in an APP-transgenic mouse model for Alzheimer’s disease
(2006)
The amyloid beta-protein (Abeta) is the main component of Alzheimer's disease (AD)-related senile plaques. In the human brain Abeta-deposition occurs in a hierarchical sequence in which different areas of the brain become ...
The role of the CC chemokine CCL17 in a mouse model of Alzheimer’s disease
(2013-07-25)
In Alzheimer's disease (AD), inflammatory processes are critically involved by cells releasing neurotoxic or neurotrophic factors influencing survival of neurons and synapses, and thereby cognitive behavior. Several ...
Neurotransmitter receptors in mouse models of Alzheimer’s disease
(2014-06-20)
Alzheimer's disease (AD) is the most common form of dementia. The disease occurs in a common sporadic and a familiar form (FAD). Both forms show a very similar clinical and pathological picture, with ß-amyloid (Aß) plaques ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
Mechanism-based Stratification of Alzheimer's and Parkinson's Disease using Artificial Intelligence
(2021-03-29)
The capacity to generate omics and clinical data in biomedical science is growing exponentially over the past decades. Additionally, recent advances in computational power and analyzing capabilities have resulted in ...
Cellular and synaptic correlates of learning and memory and their impairment in a mouse model of Alzheimer's disease
(2017-11-28)
Alzheimer's disease (AD) is characterized by synaptic dysfunction and progressive memory loss. The hippocampus is indispensable for memory processes and early affected by disease-associated pathology. It is still debated ...
The role of the chemokine receptor CXCR3 in mouse models for IL-12-driven CNS-inflammation and Morbus Alzheimer-like neurodegeneration
(2013-01-31)
The chemokine receptor CXCR3 and its corresponding ligands CXCL9, CXCL10 and CXCL11 are well known to be involved in the trafficking and migration of activated CD4+ Th1 T cells, CD8+ T cells and NK ......
Die Rolle des CXCR3 Rezeptors in Mausmodellen für IL-12 induzierter Neuroinflammation und Alzheimer-ähnlicher Neurodegeneration
Im Rahmen von Entzündungsreaktionen sind der Chemokinrezeptor CXCR3 und ......
Die Rolle des CXCR3 Rezeptors in Mausmodellen für IL-12 induzierter Neuroinflammation und Alzheimer-ähnlicher Neurodegeneration
Im Rahmen von Entzündungsreaktionen sind der Chemokinrezeptor CXCR3 und ......
Ectopic expression of the sialic acid modifying enzyme CMAH in human THP1 macrophages
(2018-09-03)
Throughout evolutionary processes, organisms gain or lose functions because of emerging mutations. The frameshift mutation emerged in the human CMAH gene is one of these loss of function mutations and it caused the human ...
Discovering lesser known molecular players and mechanistic patterns in Alzheimer's disease using an integrative disease modelling approach
(2018-12-13)
Convergence of exponentially advancing technologies is driving medical research with life changing discoveries. On the contrary, repeated failures of high-profile drugs to battle Alzheimer's disease (AD) has made it one ...
Functional in vivo calcium imaging in the hippocampus under healthy and disease conditions
(2020-04-22)
The hippocampus has long been known to be essential for all features of memory processing. Hippocampal function strongly depends on the orchestrated activity of transiently autonomous neuronal populations that create the ......