Recent advancements in healthcare practices and the increasing use of information technology in the medical domain has lead to the rapid generation of free-text data in forms of scientific articles, e-health records, ...

Das Ziel der Genetischen Epidemiologie ist DNA Sequenzvarianten im menschlichen Genom zu finden, die an der Entstehung von Krankheiten beteiligt sind. Genomweite Assoziationsstudien haben zur Identifikation von hunderten ...

The navigation of precursor cells of inhibitory interneurons from their germinal zone inside the fourth ventricle through the white matter towards their final destination within the cerebellum's molecular layer is an ongoing ...

The adaptation and evaluation of contemporary data mining methods to chemical and biological problems is one of major areas of research in chemoinformatics. Currently, large databases containing millions of small organic ...

In the postgenomic era it is impossible to annotate the majority of new proteins in any other way than with computational methods. Our tool AHRD automatically annotates proteins with human readable descriptions and Gene ...

“As the number of sequenced genomes rapidly grows, the overwhelming majority of protein products can only be annotated computationally.” (Radivojac, Clark, Oron, et al. 2013) With this goal, three new protein function ...

Even though the size of datasets in molecular analyses increased rapidly during the last years, undetected systematic errors as well as unsolved problems concerning the evaluation of data quality and adequate substitution ...

Sialic acid binding Siglecs are involved in various pathological processes. A minor fraction of Siglecs mediates activating signals via the ITAM linked DAP12 adaptor protein while the majority of Siglecs modulates inflammatory ......

The field of systems biology makes an attempt to realise various biological functions and processes as the emergent properties of the underlying biochemical network model. The area of computational systems biology deals ...

Mathematical models are in focus of modern systems biology and increasingly important to understand and manipulate complex biological systems. At the same time, new and improved techniques in metabolomics and proteomics ...