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The enzyme HPGD is critical for regulatory T cell function in adipose tissue
(2020-02-06)
Regulatory T cells (Treg cells) are essential for maintaining immune homeostasis. However, how Treg cells exert their function in tissue specific environments is often unknown. We have found ......
Contributions towards a better understanding of millipede phylogenetics and sawfly genomics
(2021-03-11)
A loss of biodiversity on a scale and rate comparable to the great extinction events, as a result of anthropogenic activity, has been documented for plants, animals, and micro-organisms. In order to foster a sustainable ...
Die Aufklärung eines neuartigen Pentose-Stoffwechsels und die Möglichkeit einer Homosuccinat-Fermentation in Darmbakterien
(2022-08-26)
In der vorliegenden Arbeit wurde der Pentose-Metabolismus des bedeutsamen Darmbakteriums Prevotella copri (P. copri) untersucht, und es wurde analysiert, ob die Umsetzung einer Homosuccinat-Fermentation mit dem Darmbakterium ......
Ökologie und Populationsstatus der Braunen Hyäne (Parahyaena brunnea, THUNBERG, 1820) auf Farmland in Namibia
(2022-10-13)
Anthropogene Ursachen wie der Verlust von Lebensräumen und die Ausbreitung von Menschensiedlungen sind die Gründe für den Rückgang der Populationen von Carnivoren. In der Vergangenheit wurden umzäunte und geschützte ......
Anthropogenic causes such as habit loss and the spread of human settlements are the reasons behind the decline in carnivore populations. In the past, fenced and protected wildlife areas were seen as a suitable measure to ......
Anthropogenic causes such as habit loss and the spread of human settlements are the reasons behind the decline in carnivore populations. In the past, fenced and protected wildlife areas were seen as a suitable measure to ......
Hippocampal network and inhibitory neuron dysfunction in age and disease
(2021-10-25)
Aging and Alzheimer’s disease (AD) are two highly intertwined pathological processes. Indeed, one of the highest risk factors for developing AD is age. Mechanistically, it has been suggested that remodeling of inhibitory ......
Profilin 2 threonine 90 phosphorylation: A regulatory mechanism
(2022-01-03)
Profilins are small actin binding proteins that interact with a plethora of ligands to fulfill their functions. These interactions were shown to be regulated by phosphorylation, also in relation to pathological conditions. ......
Inhibitory Circuits of the CA3-Dentate Gyrus System
(2021-11-04)
Neuronal inhibition is an essential feature of all brain areas. Besides controlling the average rate of neuronal firing, it also controls the precise timing of action potentials and mediates several types of network ...
Locus coeruleus modulates locomotor activity via the medial septum and the diagonal band of Broca
(2020-10-02)
The locus coeruleus (LC) is positioned in the brainstem and one of the main sources of norepinephrine in the brain. With its projections throughout the whole brain, the LC plays an important role in regulating the general ...
Deciphering the role of the deubiquitinating enzyme Ataxin-3 in transcriptional regulation and the cellular response to stress
(2018-12-19)
Ataxin-3 (ATXN3), the disease-causing protein for Machado Joseph Disease (MJD) is functionally involved in the protein quality control and transcriptional regulation of various genes. Recent data suggest that either ...