E-Dissertationen: Search
Now showing items 11-20 of 26
Untersuchungen zum Metabolismus und Nachweisfenster von γ-Hydroxybuttersäure in biologischem Material
(2018-03-19)
In dieser Arbeit wurden interdisziplinäre Untersuchungen durchgeführt, um die Nachweisbarkeitsdauer nach einer Gamma-Hydroxybuttersäure-(GHB)-Gabe in biologischen Matrices zu verlängern. Es sollten biologische Marker ...
Fast detection of protein-protein interactions with an automated FRET-based system on the flow cytometer
(2018-03-12)
Although protein-protein interactions play a major role in almost all biological functions, those interactions cannot easily be analysed, especially not on single cell level and with regard to dynamic changes in protein ...
Lipide als Transport- und Signalmoleküle: Untersuchungen in Makrophagen und Neuronen
(2018-04-17)
Lipide haben einen großen Anwendungsbereich und speziell in der Biochemie des lebenden Organismus wichtige Funktionen. Neben ihrer hauptsächlichen Funktion als Energiespeicher und Strukturkomponenten der Zellmembranen ...
The importance of endogenous opioids in feeding behavior
(2018-03-14)
Endogenous opioids are involved in a broadly distributed neural network regulating eating behavior. Opioid transmission has long been implicated in controlling hedonic and homeostatic feeding as well as regulating body ......
Functional cooperation of Toll-like receptor signaling and the high-affinity receptor for IgE, FcεRI, on human Langerhans cells
(2018-01-15)
Atopic dermatitis (AD) is a multifactorial severe skin disease with increasing incidence in western countries. In the disease, Langerhans cells (LC) play a pivotal role in bridging innate and adaptive immunity through ......
The endophytic fungus Stemphylium globuliferum – secondary metabolites and biological activities
(2018-01-22)
Fungi are a tremendous source of pharmaceutically significant compounds, e.g. the life saving immunosuppressant drug mycophenolic acid. The current project focused on the investigation of the mold fungus Stemphylium ......
Cisplatin resistance is associated with altered signalling in NSCLC cells
(2018-01-18)
The efficacy of cisplatin-based chemotherapy in cancer is limited by the occurrence of innate and acquired drug resistance. In order to better understand the mechanisms underlying acquired cisplatin resistance, the ...
The impact of dendritic calcium control on interneurons function within the hippocampal circuit
(2018-05-11)
In the past few decades, dendritic integration has been extensively studied in hippocampal excitatory cells (for review see Stuart and Spruston 2015). However, much less effort has been put into understanding inhibitory ...
Predicting Rules for Cancer Subtype Classification using Grammar-Based Genetic Programming on various Genomic Data Types
(2018-03-12)
With the advent of high-throughput methods more genomic data then ever has been generated during the past decade. As these technologies remain cost intensive and not worthwhile for every research group, databases, such as ...
Xenosialitis modulates the function of the Alzheimer’s disease associated SIGLEC3 in human THP1 macrophages
(2018-03-26)
Chronic inflammation is an undisputed feature of late onset Alzheimer’s disease (LOAD). Activated microglia,found around amyloid beta (Aβ) plaques are implicated as the source of inflammation. However they are incapable ...