E-Dissertationen: Suche
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Split Analysis Methods and Parametric Bootstrapping in Molecular Phylogenetics: Taking a closer look at model adequacy
(2015-06-08)
Even though the size of datasets in molecular analyses increased rapidly during the last years, undetected systematic errors as well as unsolved problems concerning the evaluation of data quality and adequate substitution ...
New bioactive metabolites from the marine-derived fungus Dichotomomyces cejpii and their pharmacological relevance
(2015-01-13)
Natural products from fungal sources provide an astonishing diversity of bioactive molecules. The secondary metabolite production in fungi is strongly affected by environmental influences and the isolation of fungal strains ......
Microglial sialic-acid-binding immunoglobulin-like lectin-H (Siglec-H) and Siglec-11 in neuroinflammation
(2015-01-16)
Sialic acid binding Siglecs are involved in various pathological processes. A minor fraction of Siglecs mediates activating signals via the ITAM linked DAP12 adaptor protein while the majority of Siglecs modulates inflammatory ......
Analysis of Biochemical Reaction Networks using Tropical and Polyhedral Geometry Methods
(2016-12-21)
The field of systems biology makes an attempt to realise various biological functions and processes as the emergent properties of the underlying biochemical network model. The area of computational systems biology deals ...
Mathematical Analysis and Modeling of Signaling Networks
(2017-11-24)
Mathematical models are in focus of modern systems biology and increasingly important to understand and manipulate complex biological systems. At the same time, new and improved techniques in metabolomics and proteomics ...
Beyond whole-cell motion: reactive interpenetrating flow and elliptic Voronoi tessellation in two dimensions
(2013-04-11)
A crucial property of higher-developed living beings is the ability to continuously exchange and renew their body. This is achieved by division and redistribution of cells, the micron-sized and autonomous "atoms" of life. ...
Evolution of the Activity Cliff Concept and Practical Implications for Compound Design
(2021-07-22)
Entering the “big data” era, a number of different research areas have witnessed an enormous increase in data at an exponential rate. For drug discovery, various publicly available protein structure and compound bioactivity ...
Building multiscale computable model of Alzheimer's disease and identification of novel mechanisms for new therapeutic interventions
(2018-08-28)
Despite an avalanche of data in the field of biomedicine, we are obviously not managing well to extract meaningful information from this vast amount of data to better understand complex diseases and their mechanisms. ...
Predicting Rules for Cancer Subtype Classification using Grammar-Based Genetic Programming on various Genomic Data Types
(2018-03-12)
With the advent of high-throughput methods more genomic data then ever has been generated during the past decade. As these technologies remain cost intensive and not worthwhile for every research group, databases, such as ...
Bridging between data and knowledge: New ways to better understand Alzheimer's Disease and Type 2 Diabetes comorbidity
(2021-06-15)
The holistic understanding of biological phenomena enabled by systems biology forms the basis of current research. As opposed to the principle of classical biology where behavior of a biological system is explained by ...