E-Dissertationen: Suche
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Design and Analysis of Opaque Signatures
(2011-07-04)
Digital signatures were introduced to guarantee the authenticity and integrity of the underlying messages. A digital signature scheme comprises the key generation, the signature, and the verification algorithms. The key ......
Comparison of a global submission of new biological entity and a new chemical entity: strategic decisions and criteria for implementation
(2011-06-09)
The world covers more than 190 countries in which at the moment in most of them pharmaceutical legislations and regulatory requirements are established and implemented, e.g. to describe the marketing authorization (MA) ...
γ-Secretase mediated proteolytic processing of the triggering receptor expressed on myeloid cells-2: functional implications for intracellular signaling
(2011-06-01)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, affecting millions of people worldwide. AD is histopathologically characterized by the appearance of neurofibrillary tangles, which are intraneuronal ...
Erzeugung eines ultrakalten Gases fermionischer Kaliumatome im optischen Dipolfallenpotential
(2011-05-27)
Kalte Atome können durch das induzierte elektrische Dipolmoment in Lichtfeldern gefangen werden. Liegt die Frequenz der verwendeten Lichtfelder sehr weit unterhalb aller elektronischen atomaren Resonanzen, so entsteht eine ...
Identifizierung und Charakterisierung eines neuen Inhibitors der PH-Domäne der Cytohesin-Familie
(2011-07-04)
Die Pleckstrin-homologe Domäne (PH-Domäne), die in vielen Proteinen zu finden ist, ist durch ihre Interaktion mit Phosphoinositiden (z.B. PIP3) entscheidend an der Membranrekrutierung dieser Proteine beteiligt.
Die ...
Die ...
Sensitivity of the ATLAS Experiment to discover the Decay H → ττ → ll + 4ν of the Standard Model Higgs Boson produced in Vector Boson Fusion
(2011-06-09)
A study of the expected sensitivity of the ATLAS experiment to discover the Standard Model Higgs boson produced via vector boson fusion (VBF) and its decay to H->tau->tau->ll +4nu is presented. The study is based on simulated ...
Elucidating agonist-induced signaling patterns of human G protein-coupled receptor GPR17 and uncovering pranlukast as a biased mixed agonist-antagonist at GPR17
(2011-11-15)
The progress of human genome sequencing has revealed the existence of several hundred orphan G protein-coupled receptors (GPCRs), whose endogenous ligands are not yet identified, thus their deorphanization and characterization ...
Studies on synthesis and reactions of anionic P-NR2/P-OR organophosphane complexes: Searching for the boundary between phosphanide and phosphinidenoid complexes
(2011-11-15)
This thesis was focused on the studies of synthesis and reactivity of the first Li/OR phosphinidenoid complexes, in pursuit of the boundary between phosphanide complex and phosphinidenoid complex chemistry.
First, ......
First, ......
Funktionelle Untersuchungen des ABC-Transporters Breast Cancer Resistance Protein (BCRP)
(2011-11-18)
Die Multidrug Resistenz (MDR) von Krebszellen stellt ein bedeutendes Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Vor allem die Expression der drei ABC-Transporter P-gp (ABCB1), MRP1 (ABCC1) und BCRP ...
Self-assembly of viologen molecules at metal/electrolyte interfaces under non-reactive and reactive conditions
(2011-09-19)
Nowadays, organic chemistry can synthesize almost any kind of functional organic molecules, while surface physics on the other hand provides analytical techniques of high microscopic and spectroscopic resolution. Therefore, ...