E-Dissertationen: Suche
Anzeige der Dokumente 21-30 von 59
The Control of Food Intake and Bitter Taste Information Processing in the Drosophila Larval Brain
(2016-12-22)
The regulation of feeding behavior by central neural circuits is crucial for every organism to survive. Hierarchical organized motor systems are responsible for the execution of appropriate feeding movements and can be ...
Transcriptional and epigenetic regulation of differentially activated macrophages
(2016-12-15)
Macrophages are an indispensable part of the innate immune system which mediate various functions including host defense against pathogens, metabolism, tissue homeostasis and even developmental processes. These extremely ...
N-glycosylation of intrinsic and engineered N-X-S/T motifs by Pichia pastoris can be exploited to ligate the mannose receptor but reveals no gain in immunogenicity per se
(2016-12-22)
Vaccination has the power to eradicate viral diseases and is a promising approach to cure cancer. However, modern vaccination strategies repeatedly fail in inducing a robust cytotoxic CD8+ T cell response, which ...
Vorhersagen zur Therapie-assoziierten polyklonalen Dynamik im Glioblastom anhand vergleichender Analysen vonTumor-Subklonen
(2016-12-22)
Tumoren können eine ausgeprägte zelluläre Heterogenität in genetischen und phänotypischen Merkmalen aufweisen. Uneinheitliches Ansprechen von Tumorzellen auf therapeutische Maßnahmen wird als eine mögliche Ursache für das ...
Study on the role of Cofilin 2 in the brain
(2016-12-22)
Three actin depolymerization factors are expressed in the brain, named Cofilin 1 (non-muscle Cofilin), ADF and Cofilin 2, which was long declared as muscle-specific isoform. All three members share similar biochemical ...
Die Rolle von DGD1 in dem eukaryotischen und prokaryotischen Galaktolipid-Metabolismus von Arabidopsis thaliana
(2016-12-20)
Die Galaktolipide Monogalaktosyldiacylglycerin (MGDG) und Digalaktosyldiacylglycerin (DGDG) sind die häufigsten Membranlipide der Chloroplasten. Die Biosynthese von DGDG erfolgt hauptsächlich durch die Glykosyltransferase ......
NLRP3 inflammasome activation by photooxidative damage provides a novel link between hallmark pathogenic features of age-dependent macular degeneration
(2016-12-16)
In the developed world, age-related macular degeneration (AMD) is the most common cause for severe visual loss and legal blindness in the elderly. In this progressive disease, degeneration of the retinal pigment epithelium ...
Functional characterization of Cytoplasmic Polyadenylation Element Binding proteins in the developing and diseased brain
(2016-12-22)
Gliomas are the most common primary brain tumors with aggressive progression and devastating prognosis. Therefore identification of new therapeutic and diagnostic factors is necessary to improve the dramatic situation of ...
Targeting cholesterol crystals in atherosclerosis with cholesterol solubilizing 2-hydroxypropyl-β-cyclodextrin
(2016-12-21)
Atherosclerosis is the underlying pathology of cardiovascular diseases (CVDs), the leading cause of deaths worldwide. Elevated blood cholesterol levels have been linked to this slowly progressing inflammatory disease and ......
Cholesterinkristall-Targeting in Atherosklerose mit Cholesterin lösendem 2-Hydroxypropyl-β-cyclodextrin
Kardiovaskuläre Erkrankungen sind die häufigste Todesursache weltweit. In den meisten Fällen ......
Cholesterinkristall-Targeting in Atherosklerose mit Cholesterin lösendem 2-Hydroxypropyl-β-cyclodextrin
Kardiovaskuläre Erkrankungen sind die häufigste Todesursache weltweit. In den meisten Fällen ......
The influence of hypoxia on RIG-I-mediated melanoma immunotherapy
(2016-11-29)
Hypoxia, being the inadequate tissue supply of oxygen, is a characteristic of many solid tumors that has negative implications for the patient’s prognosis. Cancer cells adapt to this hostile microenvironment by inducing ......