E-Dissertationen: Search
Now showing items 21-30 of 30
Cardiac Gαi2 Protein Function and Regulation of High-Voltage-Gated L-type Calcium Channels
(2012-05-23)
It has been proposed that the highly homologous and pertussis toxin (PTX)-sensitive cardiac Gαi isoforms, Gαi2 and Gαi3, are functionally distinct. Moreover, they are upregulated in heart ...
Molecular Analysis of the Chlamydial Anomaly: Role of the cytoskeleton protein MreB, the serine hydroxymethyl transferase GlyA and the penicillin binding proteins from Chlamydophila pneumoniae
(2012-09-27)
Chlamydiae are Gram-negative, obligate intracellular pathogens. Because of the isotonic intracellular niche of the host, a functional cell wall is dispensable in these endobacteria. Surprisingly, a nearly complete pathway ......
A2B-Adenosin-Rezeptor-Homo- und Heterodimere: Biolumineszenz-Resonanz-Energie-Transfer-Studien und pharmakologische Charakterisierung
(2012-12-12)
Die Adenosin-Rezeptoren, welche zur Superfamilie der G-Protein-gekoppelten Rezeptoren (GPCR) gehören, werden in die vier Subtypen, A1, A2A, A2B und A3 unterteilt. Aufgrund der ...
Application of Process Analytical Technology for Investigation of Fluid Bed Granulation and Active Coating during Process Development and Scale-up
(2012-12-13)
This thesis discusses the potential applications of process analytical techniques (PAT) and associated benefits of exploiting such in-line and at-line measurement tools during process development of solid dosage forms using ...
Structural remodeling of L-type calcium channel subunits in human and murine atherosclerosis
(2012-12-13)
The function of voltage-gated L-type calcium channels (LTCCs) has major impact on the function and contractility of vascular smooth muscle cells (VSMCs). The influx of external calcium regulates intracellular free calcium ...
Untersuchungen zur Optimierung der protektiven Wirkung imprägnierter Moskitonetze
(2012-11-06)
Im Rahmen der vorliegenden Arbeit zur Optimierung der protektiven Wirkung imprägnierter Moskitonetze wurde erstmals eine Multimethode entwickelt, die es ermöglicht den biologisch verfügbaren Gehalt an verschiedenen aktiven ...
Levetiracetam and Brivaracetam: Synthesis of Radioligands as Pharmacological Tools for Studying Their Interactions with Target Proteins
(2012-12-04)
Epilepsy is one of the most common neurological disorders affecting more than 50 million people worldwide. Despite extensive efforts in antiepileptic drug (AED) development it is estimated that around 30% of all epileptic ...
Quality Assurance and Safety issue of Pharmaceutical Products marketed in Developing countries
(2012-11-14)
The circulation of substandard medicines remains a serious problem in the resource limited countries like Sub-Saharan Africa, where most of the drugs available are imported. Medicines sold in these markets are frequently ......
CNP-expressing progenitors display strikingly differential oligodendroglial or multipotent fates, as assessed by two Cre reporter lines
(2012-12-21)
In this study, I employ a mouse line in which Cre is knocked-in for the 2’,3’ -cyclic nucleotide 3’ –phosphodiesterase (CNP) gene and compare the fates of CNP-Cre ex-pressing OPCs between two Cre reporters: Z/EG and ...
Untersuchungen zur Prozessüberwachung und -regulierung bei der Walzenkompaktierung mittels Drehmomenterfassung an der Granuliereinheit
(2012-09-10)
Ziel der vorliegenden Arbeit war es, eine in-line Messmethode der Schülpenfestigkeit auf Basis einer Drehmomenterfassung am Zerkleinerungsrotor der Granuliereinheit eines Walzenkompaktors zu evaluieren. Es sollte geprüft ...