E-Dissertationen: Search
Now showing items 21-30 of 312
Die Rolle von mobilen genetischen Elementen auf die Evolution von Antibiotikaresistenzen bei Staphylococcus aureus
(2011-09-27)
S. aureus ist ein bedeutender Krankheitserreger und verantwortlich für eine Vielzahl von Infektionen beim Menschen. Seine fortwährende Resistenzzunahme gegenüber nahezu allen Antibiotika, die klinisch angewendet werden, ......
Neural crest development in a human embryonic stem cell-based model system
(2012-09-03)
The neural crest is a transient embryonic cell population with outstanding characteristics. After their delamination from the closing neural tube, neural crest cells migrate extensively throughout the body and differentiate ......
Bei der Neuralleiste handelt es sich um eine transiente, embryonale Zellpopulation mit außergewöhnlichen Eigenschaften. Nach Verlassen des sich schließenden Neuralrohres migrieren die Neuralleistenzellen durch den Körper ......
Bei der Neuralleiste handelt es sich um eine transiente, embryonale Zellpopulation mit außergewöhnlichen Eigenschaften. Nach Verlassen des sich schließenden Neuralrohres migrieren die Neuralleistenzellen durch den Körper ......
Revealing the Mechanism of Thiopeptide Antibiotics at Atomistic Resolution: Implications for Rational Drug Design
(2012-07-18)
For decades drug design has primarily focused on small molecules that bind to well-formed tight binding pockets, such as the catalytic centers of enzymes. Recently, there is increasing interest to design compounds that ...
Characterization of the role of Hydroxyprostaglandin dehydrogenase 15-(NAD) in human regulatory T cells
(2012-06-14)
The focus of the present study was the characterization of the hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) in CD4+CD25+ regulatory T cells (Treg) concerning its regulation and role for the development and suppressive ...
Immunregulation durch alternative Antigenpräsentation am Beispiel der HCV- und HIV-Infektion
(2011-01-28)
Das nicht-klassische MHC-I Molekül HLA-E spielt eine bedeutende Rolle bei der Regulation der NK-Zell-vermittelten Zytotoxizität und der zytotoxischen CD8(+) T-Zellantwort. Im Gegensatz zu klassischen MHC-I Molekülen ist ...
Novel Secondary Metabolites from Endophytic Marine-derived Fungi
(2011-02-22)
The marine environment is distinguished by unique groups of organisms being the source of a wide array of fascinating structures. Marine microorganisms, such as fungi often occur associated with macroorganisms like algae, ...
The influence of gut-derived bacteria on systemic adaptive immune responses
(2010-10-07)
Sepsis and sepsis-associated multi-organ failure are major challenges for clinicians and scientists and are characterized by high patient morbidity and mortality. One factor thought to be important in the etiology of ...
Mapping the immune landscape in the alveolar space reveals alterations of multiple macrophage states in chronic obstructive pulmonary disease
(2021-03-26)
Chronic obstructive pulmonary disease (COPD) is ranked among the three leading causes of death worldwide and hence constitutes a significant burden, both medically and financially. The disease is characterized by a poorly ...
Advanced population pharmacokinetic modelling to quantify selected characteristics of drugs
(2010-08-03)
The ophthalmic lyophilisate formulation has been known for its safety, tolerability, and ability to achieve higher concentrations of a drug in the internal tissue of the eye compared with the conventional eye drop. Based ...
An anti-CD30 immunocytokine with combined IL-2 and IL-12 domains enhances anti-tumour immunity
(2010-09-24)
Classical Hodgkin’s lymphoma is one of the most curable cancers today. However, non-responders, tumour relapses and long-term toxicities of the treatment make it necessary to look for alternative drugs. In this study, we ...