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Charakterisierung von gpr17 und dessen Einfluss auf die Myelinisierung im Zebrafisch (Danio rerio)
(2018-06-05)
Der Zebrafisch (Danio rerio) ist ein karpfenartiger Süßwasserfisch, der sich aufgrund seiner schnell voranschreitenden Embryogenese und der Transparenz der Embryonen bis zum 5. Tag nach der Befruchtung der Eizelle (5 dpf) ......
The relevance of myeloid-derived suppressor cells during Litomosoides sigmodontis infection
(2018-05-23)
68 million people are infected with lymphatic filariasis (LF) in Sub-Saharan Africa, South-East Asia and South America, causing a major health problem with economic repercussions among the infected populations. This disease ......
Twin-screw Melt Granulation as alternative Granulation Strategy
(2021-07-28)
Melt granulation is an interesting alternative technique to produce both, immediate and controlled-release final products using twin-screw extruders. The aim of this current work was to gain a deeper understanding of the ...
Fast, Accurate and Steerable Segmentation of Drusen in Optical Coherence Tomography
(2020-10-05)
Age-related macular degeneration (AMD) is known to be the leading cause for blindness in developed countries. One of the early appearing biomarkers of AMD are drusen that develop between the retinal pigment epithelium (RPE) ...
The role of the salvage pathway of phytol, geranylgeraniol, and farnesol phosphorylation in Arabidopsis thaliana
(2021-03-09)
The isoprenoid alcohol phytol can be phosphorylated in Arabidopsis to phytyl-phosphate (phytyl-P) by the phytol kinase (VTE5) and further to phytyl-diphosphate (phytyl-PP) by the phytyl phosphate kinase (VTE6). Phytyl-PP ......
Handeln in riskanten Umwelten - Überlebenssicherung um welchen Preis?: Das Beispiel der Region Atakora in Nord-Benin
(2021-08-09)
Trotz Naturschutz geht das Artensterben voran und die Klimakrise erreicht fast alle Weltregionen und verursacht aufgrund von Unvorhersehbarkeiten die Destabilisierung von sozialen und ökologischen Räumen. Um einen sicheren ...
Strongly interacting few-body systems from lattice stochastic methods
(2020-08-04)
Lattice Monte Carlo plays an important role for non-perturbative descriptions of strong interactions.
Despite its success in recent years, some fundamental challenges remain.
Two of them are investigated in this work, ...
Continuous granulation and drying: Building a comprehensive process understanding based on Quality by Design principles
(2022-01-21)
This thesis investigated a complete integrated continuous granulation and drying line including the process units continuous dosing, continuous twin screw wet granulation and continuous fluid bed drying, considering also ...
The interplay of differentially γ-carboxylated vitamin K dependent proteins constitute variable VKCFD1 phenotypes
(2021-11-18)
Vitamin K dependent coagulation factor deficiency type 1 (VKCFD1) is a rare hereditary bleeding disorder caused by mutations in γ-Glutamyl carboxylase (GGCX). VKCFD1 patients are treated with high dose of vitamin K, ...
Detection of Legionella pneumophila and Pseudomonas aeruginosa and biofilm experiments in four different cooling towers (construction and biocide treatment) and evaluation of IDEXX most probable number methods in industrial water samples
(2021-11-30)
The responsible maintenance of evaporative cooling systems is an essential element in reducing the risk of the environmental dispersion of legionellae and Legionnaires’ disease outbreaks. In Germany, the 42nd Ordinance ......