E-Dissertationen: Suche
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Profilin 2 threonine 90 phosphorylation: A regulatory mechanism
(2022-01-03)
Profilins are small actin binding proteins that interact with a plethora of ligands to fulfill their functions. These interactions were shown to be regulated by phosphorylation, also in relation to pathological conditions. ......
Inhibitory Circuits of the CA3-Dentate Gyrus System
(2021-11-04)
Neuronal inhibition is an essential feature of all brain areas. Besides controlling the average rate of neuronal firing, it also controls the precise timing of action potentials and mediates several types of network ...
Locus coeruleus modulates locomotor activity via the medial septum and the diagonal band of Broca
(2020-10-02)
The locus coeruleus (LC) is positioned in the brainstem and one of the main sources of norepinephrine in the brain. With its projections throughout the whole brain, the LC plays an important role in regulating the general ...
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
Direct lineage programming - a tool to generate and analyze human cortical layer specific neurons
(2020-05-14)
Until recently, lineage commitment and differentiation have been considered to be unidirectional and irreversible. This traditional view has dramatically changed with the advent of cellular reprogramming and direct cell ......
The role of the transcription factor BCL11A in midbrain dopaminergic neurons
(2022-03-11)
Midbrain dopaminergic (mDA) neurons are located in three midbrain nuclei, the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field (RRF). mDA neurons are diverse in their developmental origin, their ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
Electrostatic anchoring of SNAP25 to the plasma membrane
(2021-07-21)
Neurotransmission is based on incredibly rapid membrane trafficking cycles, mediating the release of neurotransmitters. The fusion machinery of the well-studied SNARE protein complex ensures the speed and precision of ...
Nemertean Systematics: Usefulness of DNA Barcoding and DNA Taxonomy for Species Identification, Delimitation, and Population Analyses
(2022-04-21)
The assessment of phylogenetic relationships and systematics of all metazoan taxa heavily relies on the accurate identification and delimitation of species. For the past two centuries, both species identification and ...
Generation of an in vitro embryo model based on cellular reprogramming paradigms in embryonic stem cells
(2022-06-30)
This research project focuses on the generation and characterization of a stem cell-based organoid model system, that can model early murine embryonic development in vitro and ex utero. Such embryo-like cell culture models ......
Neuroanatomie und Funktionsmorphologie Peripherer Rezeptorneurone mit Direkten Projektionen in das Protocerebrum des Insektengehirns
(2023-04-20)
Zur Wahrnehmung unterschiedlicher thermischer Reize hat sich bei Insekten eine Reihe von Thermorezeptoren entwickelt. Der pyrophile („feuerliebend“) „Australische Feuerkäfer“ (Merimna atrata) besitzt paarige Infrarot-(IR)-Organe ......