E-Dissertationen: Search
Now showing items 41-50 of 60
Analysis of cytoplasmic sulfur trafficking during sulfur globule oxidation in Allochromatium vinosum
(2014-09-18)
The present study provides significant insights into cytoplasmic sulfurtransferases and their function in Alc. vinosum. This thesis explores the possibility of sulfur trafficking during the process of sulfur globule ...
Intrazerebroventrikuläre Enzymersatztherapie der metachromatischen Leukodystrophie
(2014-09-25)
Die metachromatische Leukodystrophie (MLD) ist eine autosomal rezessiv vererbte lysosomale Speicherkrankheit. Diese wird durch einen Gendefekt der Arylsulfatase A (ASA) verursacht, welche den ersten Schritt in der Degradation ......
Biochemical and structural studies of the interaction between ARNO and the Epidermal Growth Factor Receptor
(2014-09-18)
Receptor tyrosine kinases (RTKs) and small GTP binding proteins (GTPases) are essential regulators of multiple cellular processes, making a tight control of their activity crucial for cellular homeostasis. Recently, it was ...
Electrophysiological characterization of Na+ and T-type Ca2+ channel alterations and their impact on action potential generation in rodent models of neuropathic pain
(2014-09-19)
The pathomechanism underlying neuropathic pain is still unclear and for some diseases such as Guillain-Barré-Syndrome almost unexplored. For this, experimental autoimmune neuritis (EAN), a rat model of Guillain Barré-Syndrom ...
Identification and molecular characterisation of unknown genes involved in desiccation tolerance mechanisms in the resurrection plant Craterostigma plantagineum
(2014-11-06)
The mechanisms that enable vegetative desiccation tolerance in the resurrection plant Craterostigma plantagineum are not fully understood. Recently, transcriptome data from this plant were obtained thus providing ...
Identifikation von Kopienzahlvarianten und deren Assoziation mit neuropsychiatrischen Erkrankungen
(2014-12-08)
Die neuropsychiatrischen Erkrankungen Bipolare Störung, Majore Depression und Schizophrenie gehören zu den genetisch komplexen Erkrankungen. Zu Beginn dieser Arbeit gab es überraschende Befunde, dass spezifische, seltene ...
Charakterisierung von Subpopulationen Natürlicher Killer-Zellen bei der Hepatitis C Virus-Infektion
(2014-10-10)
Die bisher vorherrschende starre Einteilung Natürlicher Killer (NK)-Zellen in CD56Dim und CD56High Subtypen scheint zu stark vereinfacht. Es wird versucht, sich der Komplexität dieser Lymphozyten-Population ...
Die Rolle des Transkriptionsfaktors Zeb2/Sip1 in der Regulation von hämatopoetischen Stammzellen
(2014-08-29)
In dieser Arbeit wurde der Einfluss des Transkriptionsfaktors Zeb2 auf die Regulation adulter hämatopoetischer Stammzellen untersucht. Zu diesem Zwecke wurde ein konditionales, induzierbares Maus-Knockout-Modell unter ...
Role of antimicrobial peptides in metabolism and innate immunity in Drosophila melanogaster
(2014-08-12)
“Metabolism” and “Immunity” are two essential, recognized and independent functions of animal kingdom. They have their own biological cycle independent of each other. While metabolism contributes, amongst other things, to ...
Acceleration of microglial clearance function by small TREM2-activating anionic disaccharides
(2014-07-29)
Triggering receptor expressed on myeloid cells-2 (TREM2) is an innate immune receptor, which is expressed on myeloid cells, like microglia inside the central nervous system. TREM2 signals via the adaptor protein DAP12. ...