E-Dissertationen: Search
Now showing items 501-510 of 532
The relevance of myeloid-derived suppressor cells during Litomosoides sigmodontis infection
(2018-05-23)
68 million people are infected with lymphatic filariasis (LF) in Sub-Saharan Africa, South-East Asia and South America, causing a major health problem with economic repercussions among the infected populations. This disease ......
Pharmacometric modeling of fluoropyrimidines
(2023-03-07)
The fluoropyrimidine drugs fluorouracil (5FU) and capecitabine are widely used for the treatment of various solid tumors. Despite the long-term clinical experience with these drugs a substantial proportion of patients is ...
Understanding the systemic immune response in COVID-19 – one cell at a time
(2023-07-03)
(noch nicht zugänglich / not yet accessible)
Untersuchungen zur Wirkungsweise von Cervimycin
(2023-06-22)
(noch nicht zugänglich / not yet accessible)
Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84
(2021-06-21)
G protein-coupled receptors (GPCRs) are ideal drug targets. Their characteristic tissue distribution, marked ligand specificity, and their roles in countless (patho)physiological processes are being exploited by more than ...
Establishment of a Split-Combine Cell-SELEX method for Identification of Nucleobase-Modified Aptamers with Specific Binding to Androgen-independent Prostate Cancer Cells
(2023-09-11)
(noch nicht zugänglich / not yet accessible)
Regulation of inhibitory synaptic connections and distal neuronal complexity by the Ste20-like kinase Slk
(2022-11-28)
(noch nicht zugänglich / not yet accessible)
I) Characterization of LytR-CpsA-Psr enzymes and their role in Staphylococcus aureus cell wall formation
II) Elucidating the mode of action of Cacaoidin, a novel class V lantibiotic
(2022-04-04)
Antibiotic resistance poses a serious threat to human health, demanding for the discovery and development of antibiotics with resistance-breaking properties. New antibiotics should be sought with the focus on novel chemistry ...
Identification and pharmacological characterization of nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) and -4 (NPP4) inhibitors
(2022-07-29)
Ectonucleotidases are enzymes involved in different physiological functions and mainly in the regulation of purinergic signaling; in fact, they regulate the duration of purinergic receptor activation by catalyzing the ...
TREM2 modulates differential deposition of post-translationally modified Aβ variants in the brain parenchyma and the vasculature
(2022-08-01)
Alzheimer’s disease (AD) is characterized by the combined presence of extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) with abnormally phosphorylated tau (t) protein in the ...