E-Dissertationen: Search
Now showing items 51-60 of 140
Metabarcoding Invertebrate Communities in a Natural Park: From Methods to Diversity Patterns
(2021-02-22)
Biodiversity is worldwide suffering from a dramatic decline, whose underlying causes are still fairly unknown. The scientific investigation and identification of potential drivers of biodiversity loss are strongly hampered ...
Characterization of small molecule inhibitors of the NLRP3 inflammasome
(2021-08-04)
To respond quickly to infection, the innate immune system contains many germline encoded pattern recognition receptors (PRRs) that recognize a myriad of danger signals released by pathogens and damaged tissues. NLRP3 ...
GPR183 Expression on Pulmonary Conventional Dendritic Cell Type 2 Dictates Subtissular Localisation and Instructs Their Survival via the Thymic Stromal Lymphopoietin (TSLP) – TSLP Receptor (TSLPR) Axis
(2021-07-06)
Introduction: G protein-coupled receptor 183 (GPR183) is a chemotactic receptor, highly expressed by immune cells. Upon activation by its ligand, 7a,25-dihydroxycholesterol (7a,25-OHC), GPR183 activates downstream signals ......
Analyse der intranukleären Dynamik und des Exports der ribosomalen 60S-Untereinheit
(2021-09-13)
Die Proteinbiosynthese wird von Ribosomen - großen molekularen Maschinen - durchgeführt, die aus zahlreichen verschiedenen Proteinen und einem ribosomalen RNA-Rückgrat bestehen. Die Biogenese der ribosomalen Untereinheiten ...
Low Endotoxin Recovery: Wiederfindung und pyrogene Aktivität von Endotoxinen in pharmazeutischen Produkten
(2021-08-06)
Eine zuverlässige Überwachung bakterieller Kontaminationen ist entscheidend für die Herstellung und Sicherheit biopharmazeutischer Produkte. Die mikrobielle Sicherheit wird in der Regel (zusätzlich zu Sterilitätstests und ...
Fettsäure-unabhängige Anpassung bakterieller Membranen an niedrige Temperaturen
(2020-07-01)
Nach dem bisherigen Kenntnisstand der Forschung erfolgt die Kälteadaptation der bakteriellen Zellmembran durch die Änderung der Fettsäurezusammensetzung. In dieser Arbeit wurden Lebensmittel-assoziierte Isolate, deren ......
Advanced migration assays for studying chemotaxis of slow moving cells
(2021-12-16)
Chemotaxis of slow moving cells plays a crucial role in numerous physiological and pathophysiological processes; including tumour metastasis, development, and wound healing. Therefore, a comprehensive understanding of ...
Exploration of bioresources enables detection and characterization of natural products with antibacterial activities and elucidation of the corresponding biosyntheses for derivative generation
(2021-11-17)
The discovery of antibiotics in the early 20th century sparked a medicinal revolution, which for the first time in history enabled humankind to effectively combat bacterial infections. Despite this immense success, the ...
Functional impact of Kir4.1 channels in hippocampal NG2 glia on neuronal plasticity and behavior
(2020-08-25)
NG2 glia represents the 4th type of CNS glial cells. In white matter, most of them differentiate into myelinating oligodendrocytes but in grey matter a majority retains their NG2 phenotype throughout life. Intriguingly, ...
Aptamer-mediated transactivation of transcription utilizing CRISPR/Cas9 and a photoreceptor
(2021-12-16)
In synthetic biology, spatio-temporal control of molecular functions is an essential tool for the investigation and manipulation of cellular processes. The usage of light enables a reversible non-invasive trigger, that ...