E-Dissertationen: Search
Now showing items 51-59 of 59
Intramembrane proteolysis of ephrin-B2 by γ-secretase regulates podosome dynamics and migration of microglia
(2016-01-20)
The Eph-ephrin system plays pivotal roles during development and adulthood in cell-cell interaction, cell adhesion and migration. It has previously been shown that ephrin-B1 and 2 can be cleaved intramembranously by the ...
Eine neue Helfer-Funktion von T Helfer 1 Zellen bei der Induktion von CD8+ T Zellen durch sinusoidale Endothelzellen der Leber
(2016-03-17)
Die sinusoidalen Endothelzellen der Leber (LSEC) nehmen kontinuierlich zirkulierende Antigene auf und kreuzpräsentieren diese CD8+ und CD4+ T Zellen. Unter homöostatischen Bedingungen leiten LSEC die Differenzierung ...
Ultrastructure, Formation and Evolution of Chaetae in Annelids
(2016-02-02)
Annelid systematics has been quite unstable over the past century. Especially, with the introduction of molecular techniques to unravel phylogenetic relationships, previously established morphology-based phylogenetic trees ...
Sec61 mediates antigen translocation into the cytosol for cross-presentation
(2016-01-20)
The mechanisms regulating non canonical protein transport across cellular membranes are poorly understood. Cross-presentation of exogenous antigens on MHC I by dendritic cells generally require antigen translocation from ...
Investigations of D-glycero-D-ido-octulose (D-g-D-i-oct) metabolism and transketolases in the resurrection plant Craterostigma plantagineum
(2016-02-02)
Eight-carbon monosaccharides (C8H16O8) occur naturally in a number of higher plants (e.g. avocado and sedum species), but they did not get much attention in research compared to common ......
Zeb2 is essential for terminal differentiation of multiple hematopoietic lineages
(2016-01-14)
The differentiation of hematopoietic stem cells (HSC) into specialized blood cells is tightly controlled by a complex network of transcription factors (TF). The zinc finger E-Box binding TF Zeb2 is known to govern the ...
Augmin complex components control branching of sensory neuron dendrites in Drosophila larvae
(2016-02-05)
Microtubule is the major architectural element to support proper neuronal structure. It is tightly organized with intrinsic polarity and affects not only neuronal morphology but also the transport property within the cell. ......
Study on the role of nuclear Cofilin1
(2016-06-14)
Cofilin1, an actin depolymerizing factor, is a member of the ADF/Cofilin family. The ADF/Cofilin family members carry a conserved nuclear translocation signal (NTS) comprising the core amino acid sequence KKRKK. In vitro ...
Der Einfluss latenter Heparanase auf die Aktivität des Integrins VLA-4 bei Adhäsion und Migration von Melanomzellen: Ein neues Target für die antimetastatische Wirksamkeit von Heparin
(2016-01-20)
Das Enzym Heparanase nimmt in den Teilprozessen der hämatogenen Metastasierung von der Ablösung der Tumorzelle vom Primärtumor bis zur Extravasation in ein fremdes Gewebe eine wichtige Rolle ein. Es bewirkt die Degradation ...