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Rapid semi-automated phenotypic assays for compound testing in patient-derived SPG4 neurons
(2018-12-05)
Hereditary spastic paraplegia (HSP) is an inherited disease characterized by progressive spasticity in the lower limbs, caused by axonal degeneration of corticospinal motor neurons. Spastic paraplegia 4 (SPG4) is the most ...
Understanding the role of SATB1 in CD4+ T cells by analysis of conditionally targeted mice generated by genetic engineering
(2018-12-12)
Special-AT-rich-binding protein 1 (SATB1) is a nuclear protein providing higher order chromatin organization and regulation of gene expression, especially in T cells. In regulatory T cells, SATB1 is repressed to maintain ......
The role of the miR-17-92 cluster in macrophage driven innate immunity
(2018-12-11)
Research into miRNA, discovered in 1993, has exploded and revolutionized our understanding of molecular regulation in biological systems. MicroRNAs are now a well established as a regu- latory mechanism of many pathways ...
Role of the cannabinoid receptor 2 in the development of surgical neuropathic pain
(2018-12-12)
When normal nociceptive pain becomes chronic, it loses its protective function and causes a general pain hypersensitivity. Neuropathic pain is one type of chronic pain, which is caused by various diseases or physical injury ...
Cytohesin-3 und sein Interaktionspartner Arl4d regulieren die T-Zellvermittelte Immunität gegen virale Infektionen durch Beeinflussung der IL-2 Produktion
(2018-12-17)
Die Regulation der Aktivität des Immunsystems ist ein essentieller Bestandteil einer erfolgreichen Abwehr von Pathogenen durch unseren Körper. Sowohl die Aktivierung des Immunsystems als auch das Herunterfahren von ...
Funktionelle Charakterisierung eines spermienspezifischen Na+/H+-Austauschers
(2018-12-14)
Sekundär aktive Austauscher sind membranständige Proteine, die den elektrochemischen Gradienten eines Ions nutzen, um den Transport anderer Ionen oder Substrate über die Zellmembran zu ermöglichen. Natrium/Protonen ...
Preservation of Astrocytic Coupling Prevents Epileptogenesis
(2018-10-23)
Antiepileptic therapies are mainly based on drugs which target neuronal function. One third of epileptic patients do not respond adequately to these treatments and, importantly, all available drugs merely suppress seizures ......
Influence of the St John´s wort extract Ze117 and selected ingredients on membrane fluidity and phospholipid composition in rat C6 glioblastoma cells
(2018-10-31)
Chronic stress has been recognized to represent a key factor for the development of depression. Among others cortisol has been described to mediate an adaptive effect on plasma membrane fluidity which may affect signal ...
Investigation of Multipotent Neural Progenitor Cell to Oligodendrocyte Differentiation including the Transcriptional Activator Protein Pur-alpha by Quantitative Proteomics
(2019-02-26)
Oligodendrocytes are neuroglial cells, localized in the white matter of the central nervous system. They develop from neural stem cells (NSCs), which produce, among others, migrating and proliferating oligodendrocyte ...
Biophysical studies of EGFR conformation and interaction
(2019-03-26)
Epidermal growth factor receptor (EGFR) plays such a crucial role in cell signaling that its activity is intricately regulated. According to the prevailing activation model, EGF binding to EGFR initiates a series of ......