E-Dissertationen: Search
Now showing items 1-10 of 14
Prevalence of resistance-nodulation-cell division-type efflux pumps and their contribution to antimicrobial resistance in Acinetobacter baumannii
(2017-03-29)
Over the past three decades A. baumannii has evolved into a clinically important nosocomial pathogen causing epidemic outbreaks worldwide. Due to its intrinsic antimicrobial resistance and its ability to easily acquire new ......
Die externe Strahlführung für Detektortests X3ED an der Elektronen-Stretcher-Anlage ELSA
(2017-12-12)
Um das Verständnis des Aufbaus der Materie zu erweitern sind Experimente mit hochenergetischen Teilchen erforderlich. Diese Teilchenstrahlen werden beispielsweise durch Kreisbeschleuniger bereitgestellt. Aufseiten der ...
Mathematical Analysis and Modeling of Signaling Networks
(2017-11-24)
Mathematical models are in focus of modern systems biology and increasingly important to understand and manipulate complex biological systems. At the same time, new and improved techniques in metabolomics and proteomics ...
Hippocampal cellular and network properties in a mouse model of metachromatic leukodystrophy
(2017-11-30)
The human disease of metachromatic leukodystrophy (MLD) is caused by a single or multiple allelic mutations within the gene locus of arylsulfatase A (ASA). This protein is a lysosomal enzyme catalyzing the degradation of ...
On the probabilistic evaluation of decadal and paleoclimate model predictions
(2017-11-27)
The development of climate prediction systems for years to decades is an area of current research, as these time scales are important e.g. for the planning horizon of decision-makers. Those prediction systems can be improved ...
Cellular and synaptic correlates of learning and memory and their impairment in a mouse model of Alzheimer's disease
(2017-11-28)
Alzheimer's disease (AD) is characterized by synaptic dysfunction and progressive memory loss. The hippocampus is indispensable for memory processes and early affected by disease-associated pathology. It is still debated ...
Über ABCG2-Inhibitoren mit Heteroaryl-phenylamid- und Carborancarboxamid-Grundstruktur
(2017-05-17)
Der Ansatz, die Multidrug-Resistenz eines Tumors über einen Modulator bzw. Inhibitor aufzuheben, wurde in dieser Arbeit mit der Darstellung potenter, selektiver und untoxischer Hemmstoffe für den Transporter ABCG2 verfolgt ...
Atmospheric Downscaling using Multi-Objective Genetic Programming
(2017-10-10)
Numerical models are used to simulate and to understand the interplay of physical processes in the atmosphere, and to generate weather predictions and climate projections. However, due to the high computational cost of ...
Suitability Analysis of Satellite Remote Sensing Methods to Map Agricultural Land Use Change after Zimbabwe's "Fast Track Land Reform Programme"
(2017-04-06)
Forced evictions of white commercial farmers in the year 2000 took the Zimbabwean land reform programme to a new level. While international media covered the tragedies of white farmers, the collapse of a state economy and ...
Enzyme-inhibitory secondary metabolites and their exudation in the marine-derived fungus Epicoccum nigrum link
(2017-04-25)
The kingdom of fungi harbors a huge diversity of life forms. The Ascomycota in particular are a prolific source of medicinal drugs and new lead structures with potent bioactivities. During this work, two marine-derived ......