Der ubiquitär exprimierte Immunrezeptor Retinoic Acid inducible Gene-I, kurz RIG-I, ist eine zytosolisch lokalisierte Helikase, die zur Detektion von pathogenen RNA-Viren befähigt ist. Als synthetischer Ligand konnte eine ......

Epidermal growth factor receptor (EGFR) plays such a crucial role in cell signaling that its activity is intricately regulated. According to the prevailing activation model, EGF binding to EGFR initiates a series of ......

All extant mammals save the monotremes descend from an ancestor with tribosphenic tooth morphology, characterized by a distally situated crushing basin (talonid basin) on the lower and an interlocking cusp (protocone) on ......
Molarenbezahnung des Docodonten Haldanodon (Mammaliaformes) als funktionelles Analogon zu tribosphenischen Zähnen
Alle heutigen Säugetiere mit Ausnahme der Monotremen stammen von einem Vorfahren mit ......

The TAM receptors TYRO3, AXL, and MER are well characterized for their roles in cell proliferation and survival, phagocytosis, and inhibition of inflammation. The complexities of these TAM receptor responses imply a level ...

The availability of large amounts of data in public repositories provide a useful source of knowledge in the field of drug discovery. Given the increasing sizes of compound databases and volumes of activity data, computational ...

Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in the plant Cannabis sativa and the most widely used illegal drug in the world. Its consumption impairs driving skills such as keeping a vehicle on track and ...

Supersymmetry (SUSY) was proposed as one of the solutions to the hierarchy problem. In addition, R-parity (R_p) is often imposed in such models in order to e.g. avoid proton decay. These R_p -conserving ......

Clinical drug development is traditionally focused on young and middle-aged adults. The elderly are often underrepresented in clinical trials, even though persons aged 65 years and older receive the majority of drug ...

Epidermal growth factor receptor (EGFR) is often over-expressed or over-activated in cells of solid tumors and can be targeted by specific inhibitors (EGFRIs), like erlotinib, gefitinib, cetuximab and panitumumab. ...

The availability of freshwater under current and future climatic conditions remains one of the main research topics that requires an improved understanding of the terrestrial system and anthropogenic impacts. Yet, hydrologic ...