E-Dissertationen: Suche
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Characterization of VKORC1L1 with respect to VKORC1
(2019-07-10)
Vitamin K reduction is essential and catalyzed by two enzymes in vitro. Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) reduces vitamin K to sustain γ-carboxylation of vitamin K dependent (VKD) proteins. This ...
Investigation on the diversity and antimicrobial potential of marine predatory bacteria enabled elucidation of the thio-peptide kocurin and aminophenylpyrrole-derived alkaloids biosynthesis
(2019-07-17)
Bacteria are a remarkable source of bioactive compounds, of which many served as lead compounds for the development of medicinal drugs currently used for diverse applications in clinic. Despite the immense bacterial ...
Mapping intra- and inter-annual dynamics in wetlands with multispectral, thermal and SAR time series
(2019-10-23)
Kartierung der intra- und interannuellen Dynamik von Feuchtgebieten mit multispektralen, thermischen und SAR-Zeitreihen
Die Analyse der aktuellen räumlichen Verbreitung und der zeitlichen Entwicklung ...
Die Analyse der aktuellen räumlichen Verbreitung und der zeitlichen Entwicklung ...
Biophysical studies of EGFR conformation and interaction
(2019-03-26)
Epidermal growth factor receptor (EGFR) plays such a crucial role in cell signaling that its activity is intricately regulated. According to the prevailing activation model, EGF binding to EGFR initiates a series of ......
Identification of novel TAM receptor interacting proteins: Screening for novel ligands
(2019-02-07)
The TAM receptors TYRO3, AXL, and MER are well characterized for their roles in cell proliferation and survival, phagocytosis, and inhibition of inflammation. The complexities of these TAM receptor responses imply a level ...
Protein and epigenetic biomarkers for variability in epidermal growth factor receptor inhibition in cancer treatment and characterization of the inhibitor-induced skin toxicity in an in vitro model
(2019-01-31)
Epidermal growth factor receptor (EGFR) is often over-expressed or over-activated in cells of solid tumors and can be targeted by specific inhibitors (EGFRIs), like erlotinib, gefitinib, cetuximab and panitumumab. ...
Formulierung von therapeutischen Oligonukleotiden mit PAMAM-Dendrimeren zur Aktivierung von Pattern Recognition Rezeptoren des angeborenen Immunsystems
(2019-05-03)
Der ubiquitär exprimierte Immunrezeptor Retinoic Acid inducible Gene-I, kurz RIG-I, ist eine zytosolisch lokalisierte Helikase, die zur Detektion von pathogenen RNA-Viren befähigt ist. Als synthetischer Ligand konnte eine ......
Molar dentition of the docodontan Haldanodon (Mammaliaformes) as functional analog to tribosphenic teeth
(2019-06-18)
All extant mammals save the monotremes descend from an ancestor with tribosphenic tooth morphology, characterized by a distally situated crushing basin (talonid basin) on the lower and an interlocking cusp (protocone) on ......
Molarenbezahnung des Docodonten Haldanodon (Mammaliaformes) als funktionelles Analogon zu tribosphenischen Zähnen
Alle heutigen Säugetiere mit Ausnahme der Monotremen stammen von einem Vorfahren mit ......
Molarenbezahnung des Docodonten Haldanodon (Mammaliaformes) als funktionelles Analogon zu tribosphenischen Zähnen
Alle heutigen Säugetiere mit Ausnahme der Monotremen stammen von einem Vorfahren mit ......
Confronting the R-parity-violating MSSM with Flavor Observables and Displaced Vertices
(2019-06-06)
Supersymmetry (SUSY) was proposed as one of the solutions to the hierarchy problem. In addition, R-parity (Rp) is often imposed in such models in order to e.g. avoid proton decay. These Rp -conserving ......
Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...