E-Dissertationen: Suche
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Model-based formulation of amorphous solid dispersions made by hot-melt extrusion
(2019-08-21)
Regarding hot-melt extrusion in early pharmaceutical formulation and process development, techniques and procedures are needed to simplify the application of hot-melt extrusion (HME) and to decrease the effort in terms of ......
Click-SELEX enables the selection of Δ9-tetrahydrocannabinol-binding nucleic acids
(2019-05-10)
Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in the plant Cannabis sativa and the most widely used illegal drug in the world. Its consumption impairs driving skills such as keeping a vehicle on track and ...
Sphärische Lyophilisate zur pulmonalen Proteinapplikation
(2019-07-12)
Die pharmazeutische Sprüht-Gefrier-Trocknung (Spray-Freeze-Drying) umfasst ein heterogenes Feld von Technologien mit primären Anwendungen in den Bereichen Löslichkeitsverbesserung, pulmonale und nadelfreie intra-dermale ...
Development and Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Population Model for Elderly Individuals
(2019-07-04)
Clinical drug development is traditionally focused on young and middle-aged adults. The elderly are often underrepresented in clinical trials, even though persons aged 65 years and older receive the majority of drug ...
Knowledge Management approaches to model pathophysiological mechanisms and discover drug targets in Multiple Sclerosis
(2019-04-30)
Multiple Sclerosis (MS) is one of the most prevalent neurodegenerative diseases for which a cure is not yet available. MS is a complex disease for numerous reasons; its etiology is unknown, the diagnosis is not exclusive, ...
Analyzing feedbacks in a forest soil-vegetation-atmosphere system
(2019-05-03)
In this study, the soil-vegetation-atmosphere system of a 38 ha forested headwater catchment in the Eifel region (western Germany) was analyzed with the aim to improve the understanding of the impacts of climate forcings ......
In dieser Arbeit wurden verschiedene Rückkopplungen im Boden-Pflanze-Atmosphärensystem eines 38 ha großen bewaldeten Einzugsgebietes in der Eifel (Westdeutschland) analysiert. Ziel war, das Verständnis der Auswirkungen von ......
In dieser Arbeit wurden verschiedene Rückkopplungen im Boden-Pflanze-Atmosphärensystem eines 38 ha großen bewaldeten Einzugsgebietes in der Eifel (Westdeutschland) analysiert. Ziel war, das Verständnis der Auswirkungen von ......
Analysis of Multitarget Activities and Assay Interference Characteristics of Pharmaceutically Relevant Compounds
(2019-05-29)
The availability of large amounts of data in public repositories provide a useful source of knowledge in the field of drug discovery. Given the increasing sizes of compound databases and volumes of activity data, computational ...
Integrated terrestrial simulations at the continental scale: Impact of groundwater dynamics and human water use on groundwater-to-atmosphere feedbacks during the European heatwave in 2003
(2019-02-19)
The availability of freshwater under current and future climatic conditions remains one of the main research topics that requires an improved understanding of the terrestrial system and anthropogenic impacts. Yet, hydrologic ...