E-Dissertationen: Search
Now showing items 1-10 of 59
Regulation des Lipidmetabolismus in Hepatozyten
(2016-08-29)
Übergewicht, die pathologische Expansion des Fettgewebes, entsteht durch einen metabolischen Energieüberschuss. Ein konstanter Energieüberschuss führt zur Ausbildung einer komplexen Pathologie, die als metabolisches Syndrom ...
The Parkinson’s disease-related kinase Pink1 mediates mitochondrial quality control
(2016-08-29)
Mitochondrial dysfunction is a common feature of many neurodegenerative diseases, in particular Parkinson’s disease (PD). Mutations in the genes encoding the mitochondrial kinase Pink1 and the cytosolic E3 ubiquitin ligase ...
Axon regeneration following peripheral nerve lesion is driven by cofilin mediated actin turnover
(2016-09-14)
While axons of the adult peripheral nervous system (PNS) maintain the ability to regenerate, axons of the central nervous system (CNS) fail to regrow upon injury. Subsequently, trauma to the spinal cord leads to irreversible ......
The Role of Acyl-ACP Thioesterases and Glycerophosphodiester Phosphodiesterases for Gametophyte Development in Arabidopsis thaliana
(2016-08-09)
Chloroplasts are the site of the de novo synthesis of the predominant proportion of fatty acids in plant cells. The growing fatty acid chain is bound to acyl carrier protein (ACP) during synthesis. Acyl-ACP thioesterases ......
Role of the Receptor for Advanced Glycation End-products (RAGE) in the Immune Sensing of Nucleic Acids
(2016-09-06)
Nucleic acid recognition is an important mechanism that enables the innate immune system to detect both microbial infection and tissue damage. To minimize the recognition of self-derived nucleic acids, all nucleic acid ...
Biosynthesis of soluble capsule precursors in Staphylococcus aureus
(2016-11-28)
Most invasive pathogens produce polysaccharide capsules, which play an essential role in conferring protection against host immune defense. In the case of Staphylococcus aureus, most clinical isolates are encapsulated, and ......
Chelation as a strategy with the potential to overcome multidrug resistance in cancer
(2016-09-02)
According to the World Health Organisation cancer is the second leading cause of death in industrialized countries. In many cases treatment fails due to the development of resistance against multiple (structurally and ...
Analysis of the regulatory function of amino acids on metabolic targets and serotonin production in Drosophila melanogaster
(2016-08-09)
Amino acid sensing mediates metabolic and behavioural adjustments in response to organismal needs. Several pathways are believed to be involved in amino acid sensing, including the TOR (Target of Rapamycin) pathway. However, ......
Analysis of human T lymphocyte-derived immune responses against Staphylococcus aureus by delivery of in vitro transcribed antigens
(2016-07-06)
Staphylococcus aureus is a harmless commensal of the human mucosa and at the same time the main cause of life-threatening nosocomial infections worldwide. In particular, the growing number of methicillin-resistant S. aureus ...
Chemisch-molekularbiologische Studien zu Pyransynthase-Domänen in trans-AT-Polyketidsynthasen
(2016-07-21)
Im Rahmen dieser Promotionsarbeit wurde die postulierte katalytische Aktivität von Pyransynthase-Domänen (PS-Domänen) verschiedener trans-Acyltransferase-Polyketidsynthasen (trans-AT-PKS) in vitro ...