E-Dissertationen: Search
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Connectomic Analysis of a Peptidergic Circuit in Drosophila
(2017-09-21)
The homologous neuropeptides neuromedinU (NMU) and hugin have similar effects on food intake and physical activity in mammals and Drosophila, respectively. Little is known about the neuronal networks that employ either ......
Die homologen Neuropeptide NeuromedinU (NMU) und Hugin haben ähnliche Effekte auf Nahrungsaufnahme und physische Aktivität in Säugetieren bzw. Drosophila. Über die neuralen Netzwerke, in denen das jeweilige Neuropeptid ......
Die homologen Neuropeptide NeuromedinU (NMU) und Hugin haben ähnliche Effekte auf Nahrungsaufnahme und physische Aktivität in Säugetieren bzw. Drosophila. Über die neuralen Netzwerke, in denen das jeweilige Neuropeptid ......
The role of sphingosine-1-phosphate lyase (SPL) in the brain: Studies in brain-targeted SPL-deficient mice
(2017-05-15)
The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons. It was shown previously that neuronal S1P accumulation is toxic leading to ER-stress ...
Analyse der Funktion von Dynamin2 in der Integrin-vermittelten Adhäsion humaner T-Lymphozyten
(2017-11-08)
Das Immunsystem ist ein dezentralisiertes Organ, dessen zelluläre Bestandteile dazu in der Lage sein müssen, ihre Aufenthaltsorte innerhalb des Körpers rasch zu verändern, um effektive Immunantworten zu gewährleisten. So ...
Mathematical Analysis and Modeling of Signaling Networks
(2017-11-24)
Mathematical models are in focus of modern systems biology and increasingly important to understand and manipulate complex biological systems. At the same time, new and improved techniques in metabolomics and proteomics ...
Hippocampal cellular and network properties in a mouse model of metachromatic leukodystrophy
(2017-11-30)
The human disease of metachromatic leukodystrophy (MLD) is caused by a single or multiple allelic mutations within the gene locus of arylsulfatase A (ASA). This protein is a lysosomal enzyme catalyzing the degradation of ...
The role of ceramide synthase 2 in sphingosine-1-phosphate-mediated thymic egress
(2017-12-11)
A key element for effective adaptive immunity against invading pathogens is an everchanging peripheral TCR repertoire, which requires the constant release of newly formed T cells from the thymus. The process of thymic ...
Identifizierung und Charakterisierung neuer Biomarker für maligne Tumorerkrankungen
(2017-12-11)
Die Therapieoptionen sowohl im Prostatakarzinom als auch in Tumoren des Kopf- und Halsbereichs sind limitiert und die Stratifizierung der Patienten in unterschiedliche Risiko- oder Therapiegruppen muss weiter verbessert ......
Hyperspectral Imaging for Non-Invasive Characterization of Barley Resistances to Powdery Mildew
(2017-11-10)
Determination and characterization of resistance reactions of crop plants against fungal pathogens are essential to select resistant genotypes. In breeding practice phenotyping of genotypes is realized by time consuming ...
Functional characterisation of glutaredoxin S15 from Arabidopsis thaliana
(2017-12-13)
Iron-sulfur clusters (ISCs) are essential cofactors that are composed of iron and inorganic sulfur. A complex assembly pathway conveys their initial synthesis and subsequent binding to the respective apoproteins. With the ......
The role of endocannabinoid system in neuron-glial communication in the ageing and diseased brain
(2017-12-13)
The endocannabinoid system has been implicated in the regulation of glial activity and progression of brain ageing. Mice constitutively or specifically lacking the cannabinoid receptor 1 (CB1) on neurons or GABAergic neurons ...