E-Dissertationen: Search
Now showing items 1-7 of 7
Influence of disulfide-bonds on structural and functional properties of peptides and proteins - Case studies on FXIIIa inhibitor tridegin and µ-conotoxin PIIIA
(2021-05-28)
Disulfide-bonded peptides have been studied for many decades serving as tools to investigate various biochemical pathways as well as lead structures for drug development for numerous diseases. Among these, the most fatal ...
Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
(2020-02-07)
The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a ......
γ-Hydroxybuttersäure (GHB)-Analytik zum Zweck der Verlängerung des Nachweisfensters einer exogenen GHB-Gabe sowie der Verbesserung der postmortalen Befundinterpretation
(2022-06-17)
Der endogene Neurotransmitter γ-Hydroxybuttersäure (GHB) stellt Gutachter in forensisch-toxikologischen Kontexten regelmäßig vor große Herausforderungen. Im Zusammenhang mit ungeklärten Todesfällen, Suiziden oder ...
Synthesis and structure-activity relationships of CD39 and CD73 inhibitors
(2022-08-13)
Ecto-nucleoside triphosphate diphosphohydrolase-1 (NTPDase1 or CD39) is a member of the membrane-bound ecto-nucleotidase family, which catalyzes the extracellular hydrolysis of pro-inflammatory ATP and pro-thrombotic ADP ......
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84
(2021-06-21)
G protein-coupled receptors (GPCRs) are ideal drug targets. Their characteristic tissue distribution, marked ligand specificity, and their roles in countless (patho)physiological processes are being exploited by more than ...
Identification and pharmacological characterization of nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) and -4 (NPP4) inhibitors
(2022-07-29)
Ectonucleotidases are enzymes involved in different physiological functions and mainly in the regulation of purinergic signaling; in fact, they regulate the duration of purinergic receptor activation by catalyzing the ...