E-Dissertationen: Suche
Anzeige der Dokumente 71-80 von 148
Simplified intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging for liver lesion discrimination: An analysis of different analysis approaches
(2023-01-06)
Diffusion weighted imaging is one of the most promising non-invasive imaging techniques implemented in routine clinical practice and plays an important role in liver lesion characterization and discrimination. Using ...
Gibt es klinische Prädiktoren der neurogenen Dysfunktion des unteren Harntraktes bei Patienten mit Multipler Sklerose?
(2023-01-13)
Hintergrund: MS-Patienten entwickeln häufig neurogene Blasenfunktionsstörungen mit einem erhöhten Risiko für Schäden des oberen Harntraktes. Zur Diagnostik werden Miktionstagebücher, die Uroflowmetrie, der ...
Immunotherapeutic Approaches in Multiple Myeloma
(2023-12-12)
Checkpoint inhibition (CPI) has shown dramatic improvements in overall survival in many malignant diseases. However, in multiple myeloma (MM) the results were disappointing resulting in an early termination of clinical ...
Integrative Genome-Wide Analysis of Genomic and Epigenomic Data in Neuropsychiatric Disorders
(2023-01-20)
The neurobiological correlates for the development of affective disorder development are largely unknown. There is increasing evidence that epigenetic modifications e.g. DNA methylation play an important role in the ...
RIM4 deficiency leads to reduced somato-dendritic excitability of cerebellar Purkinje cells
(2023-12-14)
Synaptic function is determined by the release machinery at the active zone which is composed of a large number of synaptic proteins including RIMs. The large RIMs are key components of the presynaptic active zone that ...
The long noncoding RNA HIF1a-AS1 regulates endothelial cell function and is increased in patients with aortic valve disease and coronary artery disease
(2023-12-15)
Long noncoding RNA HIF1a-AS1 is significantly dysregulated in different CVDs. However, the specific function and the mode of action of the HIF1a-AS1 are still poorly investigated in CVD. Here, we sought to explore the ...
Extracellular Vesicles, a novel liquid biopsy marker in liver pathophysiology
(2023-07-25)
This habilitation thesis is actually spanning more than a decade of successful and high-profile laboratory research published accordingly in high cited journals as Hepatology, Gastroenterology and Journal of Hepatology. ...
Protamingabe beim interventionellen Aortenklappenersatz: Effizienz und Sicherheit zur Reduktion von Blutungskomplikationen
(2023-08-23)
Der kathetergestützte Aortenklappenersatz (TAVI) zur Behandlung einer Aortenklappenstenose erfuhr in den letzten Jahren eine stetig zunehmende Indikationsausweitung. Trotz technischer Weiterentwicklungen und steigender ...
Automated analysis of flow cytometry using deep learning for the detection of B-cell neoplasms
(2023-07-21)
B-cell neoplasms are the most prevalent type of non-Hodgkin lymphoma, including a diverse and heterogenous group of entities. Immunophenotyping with a high-throughput technology like flow cytometry is a standard diagnostic ...
Dosimetrie und Biodistribution von [68Ga]Ga-Bombesin PET/CT
(2023-07-27)
Mehr als ein Drittel der an einem Prostatakarzinom erkrankten und mittels Prostatektomie therapierten Patienten entwickelt ein Rezidiv in Form eines Anstiegs des Prostataspezifischen Antigens (PSA). In der Diagnostik kommt ...