E-Dissertationen: Suche
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Immune activation by DNA sensors in ANCA associated vasculitis
(2024-03-04)
Anti-neutrophilic cytoplasmatic antibody (ANCA) associated vasculitis (AAV) is a group of rare inflammatory autoimmune diseases primarily affecting the small vessels of kidney and lung. Current treatment options mainly ...
Influence of the Fatty Acid Saturation Levels on Inflammatory Signalling in Melanoma Cells
(2023-09-11)
Due to their rapid proliferation, tumour cells have an enhanced demand for lipids. Therefore, increased lipogenesis is considered as a hallmark of cancer. In melanoma, the lineage addiction oncogene MITF regulates the ...
Einfluss der Cyclin-abhängigen Kinase 5 auf die Expression des Programmed Cell Death Ligand 1 in murinen Pankreaskarzinomen im Vergleich verschiedener Analysemethoden
(2023-03-23)
Einleitung: Programmed Cell Death Ligand 1 (PD-L1) ist ein immuninhibitorisches Molekül, das für gewöhnlich von bestimmten Immunzellen oder dendritischen Zellen exprimiert wird. Auch verschiedene Tumoren ...
Validation, determinants and impact of medication use
(2024-04-02)
In recent decades, global medication consumption has increased substantially due to an aging population and more emphasis on preventative treatment. As medication use increases, concerns naturally arise regarding the ...
Pilzkontaminationen in Korneatransplantaten: Effektivität antimykotischer Medienzusätze und Anwendbarkeit molekularbiologischer Detektionsmethoden
(2023-10-16)
Postoperative Infektionen stellen eine schwerwiegende Komplikationen nach Korneatransplantation dar. In den letzten Jahren wurde ein Anstieg der Inzidenz von Pilzinfektionen nach Keratoplastik festgestellt. Aktuell werden ...
Impact of aging and enriched environment on α-synuclein propagation
(2022-04-06)
Parkinson's disease (PD) is the second most common neurodegenerative disease. The prevalence of sporadic PD results from a complex interaction of demographic, genetic, and environmental factors. Age is one of the strongest ...
Protein markers of inflammation and ageing in a European multi-centre dementia cohort
(2024-03-01)
Inflammation plays a key role in Alzheimerʼs disease (AD) progression. Microglia in the AD brain are exposed to pathological amyloid β (Aβ42) and tau peptide aggregates, resulting in the NLRP3 inflammasome activation ...