E-Dissertationen: Search
Now showing items 21-30 of 57
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
(2021-10-26)
Die Alzheimer-Krankheit stellt die weltweit häufigste Form der Demenz dar. Die genauen Mechanismen, welche zu ihrer Entstehung führen, sind bis heute nicht vollständig verstanden. Eine wichtige Rolle spielt die Aktivierung ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Alzheimer’s Disease is the world’s most common cause of dementia. The exact mechanisms causing neurodegeneration ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Alzheimer’s Disease is the world’s most common cause of dementia. The exact mechanisms causing neurodegeneration ......
MAIT cell diversity, function and impact on dendritic cells
(2020-04-01)
T cells represent an important component of the immune system. Whilst early studies were largely focused on the role of conventional CD8+ and CD4+ T cells that recognize peptide-antigens in association ...
The cell biology of the FcRn-albumin recycling system
(2022-08-10)
Human serum albumin (HSA) is the most abundant protein in plasma and has an exceptionally long circulatory half-life of around three weeks in humans. The enhanced half-life properties of HSA result from the selective ...
The mind's ratio: How the balance between ω-6 and ω-3 fatty acids affects the risk of late-life dementia
(2022-02-03)
Dementia health care costs are rapidly rising due to the increasing number of people with dementia worldwide that is expected to increase to 66 million by 2030 and 115 million by 2050 (Prince et al., 2013). Intensive ......
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)
The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...
Targeting the Microbiome by NLRP6 Deletion and the Development of Murine Alzheimer’s Disease
(2022-07-11)
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain
disorder. The progression of AD is characterized by the deposition of amyloid-β
peptides and hyperphosphorylated Tau proteins, causing loss ...
Investigation of Heat Shock Protein 70 and Toll-like Receptor 4 functions during inflammation reaction by mechanical compression in human periodontal ligament cells
(2021-06-24)
Biomechanical forces exerted during treatment with orthodontic appliances cause tensile and compressive strain within the periodontal ligament (PDL) of affected teeth followed by ischemia on the compression side. Further, ...
Somatic cell-derived extracellular vesicles and phenotypic outcomes in the next generation
(2023-05-31)
Evidence from both human and animal studies demonstrate that paternal experiences and exposures can cause phenotypic changes in the next generation. Extracellular vesicles (EVs) released by somatic cells are hypothesised ...
Extracellular Vesicles in Hepatobiliary Cancer Management
(2023-04-19)
Cancer is a global health problem that will intensify in the upcoming years and decades. Hepatobiliary cancers, comprising hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) and gallbladder carcinoma (GbCA), are among ...
Functions of the DEAH-box helicase DHX36 in type I interferon signaling
(2023-01-06)
The induction of type I interferons (IFN) is a hallmark of foreign nucleic acids immune sensing by the innate immune system. Based on the universal molecular structure of DNA and RNA throughout all kingdoms of life, the ...