Fakultäten der Universität Bonn: Fakultäten der Universität Bonn: Neuzugänge
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PBRM1 loss in clear cell renal cell carcinoma leads to a proangiogenic phenotype via the CXCL5/CXCR2 axis that can be targeted by CXCR2 inhibition
(2025-08-18)Immune checkpoint blockade (ICB) and anti-angiogenic tyrosine kinase inhibitors (TKI) have substantially improved the outcomes of metastatic clear cell renal cell carcinoma (ccRCC). Nevertheless, the anti-angiogenic TKIs ... -
Fitness Valleys, Metastability and Changing Environments
(2025-08-18)Mathematical modelling of biological processes has become an area of high scientific interest. This field has expanded substantially over the past century and developed a wide variety of mathematical approaches and biological ... -
Molecular insights into abiotic stress responses in barley and Arabidopsis
(2025-08-18)This cumulative thesis, titled "Molecular insights into abiotic stress responses in barley and Arabidopsis", investigates two critical aspects of plant responses to abiotic stress. The first part explores hydrogen peroxide ... -
Postoperative Nervus femoralis Läsionen in der gynäkologischen Onkologie
(2025-08-18)Die meisten Verletzungen des Nervus femoralis sind iatrogen bedingt und treten nach chirurgischen Eingriffen auf. Auch wenn sie meist eine gute Prognose haben, kann eine spontane Heilung Monate andauern und somit den ... -
Einfluss von hypoxisch-ischämischem Hirnschaden auf die Neurogenese und das strukturelle sowie funktionelle Outcome im Rattenmodell
(2025-08-15)<strong>Hintergrund und Zielsetzung:</strong><br/> Die hypoxisch-ischämische Enzephalopathie (HIE) bei Neugeborenen entsteht durch eine mangelhafte Versorgung des Gehirns mit Sauerstoff und Nährstoffen rund um die Geburt. ... -
Ärztliches Verordnungsverhalten von Laboranalysen am Beispiel des Serummagnesiums: Eine Vorher-/Nachher-Studie mit unterbrochenen Zeitreihen
(2025-08-13)Die strukturellen Einflüsse auf die Entscheidungsfindung in der medizinischen Versorgung wurden bislang nur unzureichend untersucht. <br/> Die durchgeführte Studie widmet sich einem Teilaspekt dieser Problemstellung, indem ... -
Evaluation and homogenization of a marine gravity database from shipborne and satellite altimetry-derived gravity data over the coastal region of Nigeria
(2024-09-10)Accurate geoid modelling in marine areas requires the integration of gravity data from multiple sources including shipborne gravity measurements, global geopotential models, and satellite altimetry-derived gravity data. ... -
33/m: Komplettierung des Impfstatus vor Praktikum in Kindertagesstätte: Vorbereitung auf die Facharztprüfung: Fall 52
(2024-07-11)<strong>Prüfungssimulation</strong><br /> <strong><em>Fallschilderung</strong></em><br /> Ein 33-jähriger Student des Fachs Kindheitspädagogik möchte in 6 Wochen sein erstes Praktikum in einer Kindertagesstätte ... -
Mouse models of type I interferonopathies
(2024-12-16)Type I interferonopathies are severe monogenic diseases caused by mutations that result in chronically upregulated production of type I interferon. They present with a broad variety of symptoms, the mechanisms of which are ... -
IDEAL–compliant implementation of the Dexter® surgical robot in cholecystectomy: A comprehensive framework and clinical outcomes
(2024-12-30)<strong>Objectives:</strong> The integration of advanced technologies is transforming surgical practice, particularly through robotic systems. This study presents the early clinical implementation of the Dexter<sup>®</sup> ... -
Longitudinal Study of SARS-CoV-2 Vaccinations and Infections in Patients with Gastrointestinal Cancer: Stabilizing Immune Responses and Neutralizing Emerging Variants with Variant-Adapted Antigen Exposures
(2024-12-19)This longitudinal study examined how active gastrointestinal (GI) cancer types affect immune responses to SARS-CoV-2, focusing on the ability to neutralize the Omicron variants. Patients with GI cancer (<em>n</em> = 168) ... -
Regulatory T Cell Inhibition by P60 Combined with Adenoviral AFP Transduced Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma
(2023-10-17)<strong>Background & Aims:</strong> Vaccination with tumor-associated antigen-pulsed dendritic cells leads to specific T-cell response against hepato-cellular carcinoma. However, clinical response has been shown to be ... -
Tackling Structural Injustices: On the Entanglement of Visibility and Justice in Emerging Technologies
(2023-06-20)In today's world, Artificial Intelligence plays a central role in many decision-making processes. However, its use can lead to structural and epistemic injustices— especially in the context of health. In 2019, for example, ... -
Epidemiology and outcomes of vancomycin-resistant enterococcus infections: A systematic review and meta-analysis
(2023-09-19)Vancomycin-resistant enterococci (VRE) cause many infections in the healthcare context. Knowledge regarding the epidemiology and burden of VRE infections, however, remains fragmented. We aimed to summarize recent studies ... -
Evaluating AI Courses: A Valid and Reliable Instrument for Assessing Artificial-Intelligence Learning through Comparative Self-Assessment
(2023-09-26)A growing number of courses seek to increase the basic artificial-intelligence skills ("AI literacy") of their participants. At this time, there is no valid and reliable measurement tool that can be used to assess AI-learning ... -
The European Research Infrastructure Consortium (ERIC) as the New Normal?: Change and Continuity in Organising European Research Infrastructures since the Early 2000s
(2024)The establishment of Research Infrastructures in Europe, often referred to as Big Science, has been a consistent focus of ad-hoc intergovernmental politics among member states and international partners since the latter ... -
Spatially Resolved Association of Structural Biomarkers on Retinal Function in Non-Exudative Age-Related Macular Degeneration Over 4 Years
(2024-04-30)<strong>PURPOSE.</strong> To longitudinally assess the impact of high-risk structural biomarkers for natural disease progression in non-exudative age-related macular degeneration (AMD) on spatially resolved mesopic and ... -
Key factors for sustainable working conditions in emergency departments: An EUSEM-initiated, Europe-wide consensus survey
(2025-02)<em>Background and importance</em> Modern emergency medicine (EM) is a complex, demanding, and occasionally stressful field of work. Working conditions, provider well-being, and associated health and performance outcomes ... -
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function
(2024-04-29)Promoting brown adipose tissue (BAT) activity innovatively targetsobesity and metabolic disease. While thermogenic activation of BAT is wellunderstood, the rheostatic regulation of BAT to avoid excessive energy dissipation ... -
Exploring the role of tryptophan in biennial bearing: A mobile molecule that is exported from growing apples but does not suppress flowering
(2024-12-23)<em>Background of the study</em> – <strong>Apple (<em>Malus × domestica</em> Borkh.) production faces significant challenges, with biennial (or alternate) bearing being a major obstacle to stable yields. Natural high crop ...
