The Faculty of Mathematics and Natural Sciences: Browsing Mathematisch-Naturwissenschaftliche Fakultät by Title
Now showing items 1315-1334 of 4586
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Erzeugung und Charakterisierung eines Hepatoma-derived Growth Factor (HDGF) -defizienten Mausmodells
Gallitzendörfer, Rainer (2011-09-19)Der <em>Hepatoma-derived growth factor</em> (HDGF) bildet zusammen mit den ihm verwandten Proteinen (HRP-1-4 und LEDGF) eine Familie großer, proteinerger Wachstumsfaktoren. Aufgrund seiner ausgeprägten Expression während ... -
Erzeugung und Charakterisierung verschiedener Mauslinien zur zelltypspezifischen Deletion, Expression und Substitution von Connexingenen
Döring, Britta (2005)Im Rahmen dieser Arbeit wurde mit Hilfe verschiedener transgener Mausmodelle die Funktion unterschiedlicher Vertreter der Connexin-Genfamilie untersucht.<br /> Durch die Erzeugung von Cx43<sup>fl/fl</sup>:SM-CreER<sup>T2 ... -
Erzeugung und erste Charakterisierungen zweier Mausmutanten mit Defekten in der Ceramidsynthase 2 und 4
Imgrund, Silke (2012-01-06)Die Genfamilie der Maus Ceramidsynthase besteht aus sechs Mitgliedern, CerS1-CerS6, die für gewebespezifische und Fettsäureacyl-CoA abhängige Ceramidsynthasen kodieren. Im Rahmen dieser Doktorarbeit sollte die Charakterisierung ... -
Erzeugung und Untersuchung neuer transgener Mausmutanten zur Expression und Funktion der Connexine während der Myogenese
Freiin von Maltzahn, Julia (2008)<p>Im Rahmen der vorliegenden Arbeit wurde die Expression und Funktion der Connexine während der Myogenese untersucht. Die Myoblasten sind durch die Expression des Connexin43 (Cx43) gekennzeichnet, während in Myotuben nur ... -
Erzeugung von Nanostrukturen mit laserpräparierten thermischen Atomstrahlen
Mützel, Mario (2004)Gegenstand dieser Arbeit ist die Erzeugung von Nanostrukturen mit optisch kollimierten, thermischen Atomstrahlen. Im ersten Teil (Kap. 2-4) werden neue Konzepte und Experimente zur Atomlithografie mit Dipolkraft-Lichtmasken ... -
ESCRT in der Makrophageninfektion durch Rhodococcus equi
Haubenthal, Thomas Arndt (2024-01-22)(noch nicht zugänglich / not yet accessible) -
Das essentielle YycFGHI-Regulationssystem von Staphylococcus aureus: Charakterisierung von Überexpressions-Mutanten und die Etablierung zweier in vitro-Modellsysteme
Türck, Michael (2009-10-08)Bei dem essentiellen Zwei-Komponenten-Regulationssystem (TCS, two-component regulatory system) YycFG handelt es sich um ein hochkonserviertes System, das aus der Sensor-Histidin-Kinase YycG und ihrem zugehörigen Responseregulator ... -
Establishing a Comprehensive Toolbox for Isotopic Labelling Studies on Terpene Synthases
Rinkel, Jan (2019-11-08)The cumulative doctoral thesis "Establishing a Comprehensive Toolbox for Isotopic Labelling Studies on Terpene Synthases" describes the synthesis and application of isotopically labelled compounds for the systematic in ... -
Establishing blood-based classifiers for decentralized and privacy-preserving disease prediction
Warnat-Herresthal, Stefanie (2024-04-08)Big data is increasingly being generated across all sectors of medicine and high-dimensional omics data have been shown to be a powerful data space for AI applications that can assist in primary and differential diagnostics, ... -
Establishing SNPSTR Markers to Fight Illegal Wildlife Trade
Mozer, Annika (2024-07-04)(noch nicht zugänglich / not yet accessible) -
Establishment of a cell-based anti-prion compound screen and analysis of host response to prion infection in cerebellar organotypic slice cultures
Zielinski, Catharina (2019-02-19)Prions are unconventional infectious agents that cause always fatal neurodegenerative diseases termed prion disease or transmissible spongiform encephalopathies in mammals. Prion diseases are caused by an accumulation of ... -
Establishment of a Split-Combine Cell-SELEX method for Identification of Nucleobase-Modified Aptamers with Specific Binding to Androgen-independent Prostate Cancer Cells
Choukeife, Moujab (2023-09-11)Prostate cancer is the most commonly diagnosed malignancy and the second leading cause of cancer-related mortality in men in the United States. Current therapies, such as chemotherapy, radiotherapy, and photothermal therapy, ... -
Establishment of a transgenic system for in vivo detection of apoptosis in the developing heart
Martínez Lagunas, Kristel (2018-07-20)All living organisms face death since the beginning of their lives. Cells commit suicide to sculpt correctly all organs during animal development. Currently, there exist at least 13 cell death modalities through which a ... -
Establishment of anti-apoptotic brakes in human neurons during maturation
Kleinsimlinghaus, Karolina (2019-11-29)Neurons represent a highly specialised cell population of the central and peripheral nervous system, which is responsible for spreading information throughout the body. They are born during embryonic development and persist ... -
Establishment of Embryonic Stem Cell Derived Microglial Precursors and Application in an Animal Model of Alzheimer’s Disease
Napoli, Isabella (2008)The role of microglia in Alzheimer’s disease (AD) is controversial, as it remains unclear if the microglia form the amyloid fibrils or react to them in a phagocytic role. However, there has been recognition that microglia ... -
Establishment of microglial precursors derived from human induced pluripotent stem cells to model SOD1-mediated amyotrophic lateral sclerosis
Roy, Kristin (2013-04-16)Microglia, the resident immune cells of the central nervous system (CNS), are responsible for tissue homeostasis and host defense. After activation, they can also be involved in a wide range of neurodegenerative diseases ... -
Establishment of predictive blood-based signatures in medical large scale genomic data sets: Development of novel diagnostic tests
Hofmann, Andrea (2013-07-16)Increasing data has led to tremendous success in discovering molecular biomarkers based on high throughput data. However, the translation of these so-called genomic signatures into clinical practice has been limited. The ... -
Estimates for generalized sparse grid hierarchical basis preconditioners
Peter Oswald (2018-03)We reconsider some estimates from the 1994 paper [6] concerning the hierarchical basis preconditioner for sparse grid discretizations. The improvement is in three directions: We consider arbitrary space dimensions <em>d</em> ... -
Estimating sauropod body mass and gait: by the analysis of recent and fossil tetrapod tracks with photogrammetry and soil mechanics
Läbe, Sashima (2017-08-15)This dissertation presents an analysis of recent and fossil tracks with quantitative and in-terdisciplinary methods for estimating the body mass and locomotion of a sauropod trackmaker. By employing methods from natural ... -
Estimation of Distribution Algorithms and Minimum Relative Entropy
Höns, Robin (2006)In the field of optimization using probabilistic models of the search space, this thesis identifies and elaborates several advancements in which the principles of maximum entropy and minimum relative entropy from information ...