The Faculty of Mathematics and Natural Sciences: Browsing Mathematisch-Naturwissenschaftliche Fakultät by Title
Now showing items 399-418 of 4588
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Beyond whole-cell motion: reactive interpenetrating flow and elliptic Voronoi tessellation in two dimensions
Bock, Martin (2013-04-11)A crucial property of higher-developed living beings is the ability to continuously exchange and renew their body. This is achieved by division and redistribution of cells, the micron-sized and autonomous "atoms" of life. ... -
Beyond Worst-Case Analysis of Max-Cut and Local Search
Etscheid, Michael (2018-08-15)Since the formal definition of NP-completeness, there has been a huge discrepancy between theory and practice. The theoretical point of view for an NP-complete problem is that we do not know of any efficient, that is, ... -
Beziehungen zwischen Niederschlag und Abfluss bei großen Sommerhochwassern
Pardé, Maurice (1954)Der Wasserhaushalt von Flußgebieten und Landschaften als Teil des irdischen Naturgeschehens rückt heute immer stärker in das öffentliche Interesse, je mehr man erkennt, daß nicht nur Klima, Gelände und Boden, sondern auch ... -
The bidirectional link between visual processing and optomotor flight behavior in Drosophila
Fischer, Philippe Jules (2024-09-02)Animals that explore the world need to reliably move in a preplanned direction. With the optomotor response, flies stabilize a straight path during flight by visual feedback. Unintended deviations from a straight path are ... -
Bifunktionelle Katalysatoren auf Rotaxanbasis als Modelle für Multienzymkomplexe
Beizai, Kaweh Michael (2002)Die Chemie der nicht-kovalenten Bindung, die über das einzelne, isolierte Molekül hinausgeht, wird als Supramolekulare Chemie bezeichnet und erfährt in der aktuellen Forschung ein stürmisches Wachstum.<br /> Als Vorbild ... -
Bildgebung mit DEPFET-Pixelmatrizen für autoradiographische Anwendungen
Ulrici, Johannes (2003)DEPFET Pixel Sensors offer a very good spatial, time and energy resolution at the same time, thus opening new possibilities in low noise biomedical imaging as well as in particle physics and astronomy. In the DEPFET pixel ... -
Bildungsmechanismus und physiologische Relevanz supramolekularer Proteincluster des Amyloid Precursor Protein APP in der Zellmembran
Schreiber, Arne (2013-01-09)Proteine in biologischen Membranen sind in der Regel heterogen in Domänen organisiert. Die Mechanismen dieser Segregation in Membranproteincluster unterschiedlicher Zusammensetzung sind noch immer unverstanden. <br /> Auch ... -
Binary star population synthesis: Progenitors of gravitational wave driven mergers
Kruckow, Matthias U. (2018-06-13)The vast majority of all massive stars are born in binaries. The binarity of a star may influence its life drastically via a large variety of interactions with its companion star. Several astrophysical events, like the ... -
The Binding Behavior of Daptomycin on the Bacterial Membranes
Liu, Xinliang (2018-07-24)Daptomycin (DAP) is a cyclic anionic lipopeptide antibiotic that kills gram-positive bacteria via cell membrane distortion. It is currently approved for treatment of complicated infections caused by gram-positive bacteria, ... -
Binding of cytohesin 2 to the plasma membrane and its relationship with the EGFR
Karnowski, Nora (2018-11-06)Eukaryotic cells are compartmentalized by lipid membranes to achieve the spatial separation of biological processes and signaling pathways. Controlled trafficking of proteins between these compartments as well as the ... -
Bindung, Funktion und Signalwegbevorzugung von orthosterischen, allosterischen und Hybridliganden vermittelt durch Wildtyp und punktmutierte muskarinische hM1-hM5-Rezeptoren
Irmen, Matthias (2021-12-16)Bislang war ungeklärt, ob der Arzneistoff Methantheliniumbromid (MB) (Vagantin®) mit muskarinischen Acetylcholinrezeptoren (<em>h</em>M-Rezeptoren) interagiert (Teilprojekt 1). In umfassenden Untersuchungen konnte erstmalig ... -
Bindungstopografie allosterisch/orthosterischer Hybridagonisten an M2-Acetylcholinrezeptoren
Antony, Johannes (2008)Muskarinische Acetylcholinrezeptoren besitzen neben der konventionellen, orthosterischen Bindungsstelle für Liganden wie den endogenen Agonisten Acetylcholin oder den Antagonisten N-Methylscopolamin ein weiteres spezifisches ... -
Biochemical and cell culture approach to study the molecular aspects of Metachromatic Leukodystrophy
Karumbayaram, Saravanan (2006)Metachromatic leukodystrophy (MLD) is a lysosomal lipid storage disease caused by arylsulfatase A deficiency. In MLD patients, the sphingolipid sulfatide increasingly accumulates leading to progressive demyelination. In ... -
Biochemical and functional analysis of innexin2-containing gap junction channels during organogenesis in Drosophila
Lechner, Hildegard (2009-05-13)Gap junctions channels serve as mediators for direct cell-to cell communication between cells of different tissues and organs by the exchange of small metabolites and signalling molecules. They are formed by analogous ... -
Biochemical and genetic analysis of the Sox multienzyme complex in the purple sulfur bacterium Allochromatium vinosum
Hensen, Daniela (2006)The best studied pathway of thiosulfate oxidation is the complete transformation to sulfate by a <i>sox</i> encoded periplasmic multienzyme complex. In the chemotroph <i>Paracoccus pantotrophus</i> Sox proteins are essential ... -
Biochemical and structural characterization of the NLRP3 inflammasome
Brinkschulte, Hildegard Maria Rebecca (2020-02-13)The innate immune system utilizes inflammasome proteins to recognize danger signals and to fight invading pathogens. To date, the most studied inflammasome protein is NLRP3 - a multidomain protein, composed of a N-terminal ... -
Biochemical and Structural Characterization of β-Hydroxylases in Non-Ribosomal Peptide Biosynthesis
Wirtz, Daniel A. (2022-02-02)Hydroxylases are essential in the biosynthesis of natural products by functionalization of building blocks, which derive from primary metabolism. They provide hydrophily for specific interactions or enable further ... -
Biochemical and structural studies of NOD-like receptors and their inhibition by small molecule inhibitors
Marleaux, Michael (2023-03-07)NOD-like receptors (NLRs) are innate immune sensors that can form inflammasomes driving pyroptosis. NLRP3 is the best studied member of the NLRs to date, and its dysregulation has been linked to human diseases relevant to ... -
Biochemical and structural studies of the interaction between ARNO and the Epidermal Growth Factor Receptor
Weiche, Benjamin Felix Crispin (2014-09-18)Receptor tyrosine kinases (RTKs) and small GTP binding proteins (GTPases) are essential regulators of multiple cellular processes, making a tight control of their activity crucial for cellular homeostasis. Recently, it was ... -
Biochemical characterization of the human Cyclin-dependent kinases Cdk7 and Cdk10
Düster, Robert Salim (2021-08-13)Protein kinases comprise a large superfamily of enzymes regulating a plethora of cellular processes. Dysregulation of protein kinases, such as loss of activity, hyperactivity or mislocalisation, is often accompanied with ...