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    • Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors 

      Klausen, Christina; Kaiser, Fabian; Stüven, Birthe; Hansen, Jan N.; Wachten, Dagmar (2019-11-14)
      The second messenger 3´, 5´-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil ...

    • How to control cyclic nucleotide signaling by light 

      Jansen, Vera; Jikeli, Jan F.; Wachten, Dagmar (2017-03-10)
      Optogenetics allows to non-invasively manipulate cellular functions with spatio-temporal precision by combining genetic engineering with the control of protein function by light. Since the discovery of channelrhodopsin has ...

    • Shedding light on the role of cAMP in mammalian sperm physiology 

      Balbach, Melanie; Beckert, Vera; Hansen, Jan N.; Wachten, Dagmar (2018-06-15)
      Mammalian fertilization relies on sperm finding the egg and penetrating the egg vestments. All steps in a sperm's lifetime crucially rely on changes in the second messenger cAMP (cyclic adenosine monophosphate). In recent ...