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Anzeige der Dokumente 10979-10998 von 12356
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T cell response to an MHC-II restricted epitope of rodent malaria
(2022-02-01)Malaria is caused by different <em>Plasmodium</em> species that can infect a variety of animals including humans and rodents. The life cycle of these parasites is complex and includes a liver stage followed by a blood-stage ... -
T-Zellen mit komplementierenden chimären Antigen-Rezeptoren haben eine erniedrigte Aktivierungsschwelle bei der Erkennung von Antigen-Mustern
(2015-11-16)Die adoptive Immuntherapie mit chimären Antigen Rezeptor (CAR) modifizierten T Zellen erzielte kürzlich spektakuläre Erfolge in der Therapie leukämischer Erkrankungen, jedoch zeigten sich bei der Behandlung solider Tumore ... -
The T2TM Tibia Nail: A Prospective Multicenter Clinical Study
(2016-06-28)In this prospective multicenter clinical study 102 patients with a tibial fracture were operated with the reamed T2<strong><sup>TM</sup></strong> Stryker tibia nail system in 3 European Level 1 Traumacenters during 01-2003 ... -
Tackling Structural Injustices: On the Entanglement of Visibility and Justice in Emerging Technologies
(2023-06-20)In today's world, Artificial Intelligence plays a central role in many decision-making processes. However, its use can lead to structural and epistemic injustices— especially in the context of health. In 2019, for example, ... -
The Tagging System of the BGO-OD experiment
(2015-06-17)In the course of my PhD work, I have been involved in the development and the construction of the Tagging System for the BGO-OD experiment at the ELSA accelerators of the University of Bonn.<br /> BGO-OD is a fixed target ... -
A Tale of Two Wide Separation Gravitational Lenses
(2008)<p>Wide separation gravitational lens systems are good candidates to probe the matter (luminous+dark) distribution in massive halos. Investigation of two wide separation lens systems is carried out. MG 2016+112 is a quadruply ... -
Talentierte symbiontische Naturstoffproduzenten als Quelle neuer Wirkstoffe
(2020-03-03)Zunehmende Resistenzen und gleichzeitig sinkende Zahlen neu zugelassener Antibiotika lassen den Bedarf an neuen antibiotischen Wirkstoffen steigen. Aber auch in anderen medizinischen Bereichen wie z. B. der Onkologie ist ... -
Tales of Heritagization: Networks, flows and community involvement at World Heritage sites in Vietnam
(2021-12-08)The study entangles the relation between World heritage (WH) – as a selective process termed as heritagization, and community – as a heterogeneous construct. It holds three key objectives. First, it aims to deconstruct the ... -
Tales of migration without wage differentials: Individual, family, and community contexts
(2003-09)By means of examples that pertain to individual, family, and community contexts, it is shown that migration between locations is compatible with a zero expected net earnings differential between locations. The examples ... -
Taming Hadronic Effects at the Precision Frontier: From the Muon Anomaly to Rare Decays
(2021-02-01)The strong interaction, one of the indispensable pillars of the Standard Model of particle physics, poses challenges at low energies because of the phase transition and the confinement nature of its underlying theory, ... -
Tangent and normal cones for low-rank matrices
(2017-10)In [D. R. Luke, <em>J. Math. Imaging Vision</em>, 47(3):231-238, 2013] the structure of the Mordukhovich normal cone to varieties of low rank matrices at rank-deficient points has been determined. A simplified proof of ... -
Taphonomie des Howe Quarry’s (Morrison-Formation, Oberer Jura), Bighorn County, Wyoming, USA
(2004)Der Howe Quarry in Nordwyoming dokumentiert ein Massenvorkommen an Sauropoden der Morrison Formation (Oberer Jura, Kimmeridgium-Tithonium). Das Ziel dieser Arbeit ist Antworten zur Paläobiologie der Sauropoden durch Studium ... -
Tapping Potentials of Innovation for African Food Security and Sustainable Agricultural Growth: an Africa-wide Perspective
(2015-09)While in the past, increased use of inputs and expansion of agricultural land accounted for a good part of agricultural growth in Africa, improvements in productivity will need to be a major driver of growth in the future. ... -
TAR DNA-binding Protein 43 as a Damage-associated Molecular Pattern in Amyotrophic Lateral Sclerosis-related Neuroinflammation
(2024-01-10)ALS as one of the most common and aggressive neuromuscular diseases is characterized by rapidly progressing and, in later stages, generalized muscular decline. As of today, limited therapeutic options exist and there is ... -
Target-based discovery of novel inhibitors of enzymatic targets from Wolbachia endosymbionts and evaluation as antifilarial drug candidates
(2013-07-24)Filarial nematodes are the causative agents of vector-borne diseases known as lymphatic filariasis and onchocerciasis. More than 150 million inhabitants of endemic tropical and subtropical countries are infected and may ... -
Targeted cytokine-induced killer cells in non-small cell lung cancer
(2024-04-03)<strong>STUDY I: A Combination of Cytokine-Induced Killer Cells With PD-1 Blockade and ALK Inhibitor Showed Substantial Intrinsic Variability Across Non-Small Cell Lung</strong> <br /> <strong>Background: </strong> Cancer ... -
Targeted editing of DNA methylation: Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma
(2024-09-05)Glioblastoma is the most common and aggressive primary tumor of the central nervous system with poor outcome. Current gold standard treatment is surgical resection followed by a combination of radio- and chemotherapy. ... -
Targeted Fast Radio Burst Searches with the Efflesberg 100-m Radio Telescope
(2021-03-24)Fast radio bursts (FRBs) are bright, energetic, millisecond duration radio bursts of extragalactic origin. The source of FRBs still remains an open problem. Since the discovery of FRBs in 2007, over 100 FRBs have been ... -
Targeted therapeutics against cancer and infections Identification and characterization of human ecto-nucleotidase (CD39) and coronaviral protease (Mpro) inhibitors
(2022-09-28)The main objectives of this thesis were the development, characterization and optimization of enzyme inhibitors (i) for the human ecto-nucleotidase CD39, and (ii) for the main protease of the human-pathogenic coronavirus ... -
Targeted therapy of DC-CIK cells in renal cell carcinoma
(2023-03-24)CIK cells are a heterogeneous population of exceptional T lymphocytes with CD3+CD56+ cells as the primary effectors. CIK cells in combination with DCs have exhibited promising clinical effects on patients with RCC as ...
