E-Dissertationen: Auflistung E-Dissertationen nach Titel
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T-Zellen mit komplementierenden chimären Antigen-Rezeptoren haben eine erniedrigte Aktivierungsschwelle bei der Erkennung von Antigen-Mustern
(2015-11-16)Die adoptive Immuntherapie mit chimären Antigen Rezeptor (CAR) modifizierten T Zellen erzielte kürzlich spektakuläre Erfolge in der Therapie leukämischer Erkrankungen, jedoch zeigten sich bei der Behandlung solider Tumore ... -
The Tagging System of the BGO-OD experiment
(2015-06-17)In the course of my PhD work, I have been involved in the development and the construction of the Tagging System for the BGO-OD experiment at the ELSA accelerators of the University of Bonn.<br /> BGO-OD is a fixed target ... -
A Tale of Two Wide Separation Gravitational Lenses
(2008)<p>Wide separation gravitational lens systems are good candidates to probe the matter (luminous+dark) distribution in massive halos. Investigation of two wide separation lens systems is carried out. MG 2016+112 is a quadruply ... -
Talentierte symbiontische Naturstoffproduzenten als Quelle neuer Wirkstoffe
(2020-03-03)Zunehmende Resistenzen und gleichzeitig sinkende Zahlen neu zugelassener Antibiotika lassen den Bedarf an neuen antibiotischen Wirkstoffen steigen. Aber auch in anderen medizinischen Bereichen wie z. B. der Onkologie ist ... -
Taming Hadronic Effects at the Precision Frontier: From the Muon Anomaly to Rare Decays
(2021-02-01)The strong interaction, one of the indispensable pillars of the Standard Model of particle physics, poses challenges at low energies because of the phase transition and the confinement nature of its underlying theory, ... -
Taphonomie des Howe Quarry’s (Morrison-Formation, Oberer Jura), Bighorn County, Wyoming, USA
(2004)Der Howe Quarry in Nordwyoming dokumentiert ein Massenvorkommen an Sauropoden der Morrison Formation (Oberer Jura, Kimmeridgium-Tithonium). Das Ziel dieser Arbeit ist Antworten zur Paläobiologie der Sauropoden durch Studium ... -
Target-based discovery of novel inhibitors of enzymatic targets from Wolbachia endosymbionts and evaluation as antifilarial drug candidates
(2013-07-24)Filarial nematodes are the causative agents of vector-borne diseases known as lymphatic filariasis and onchocerciasis. More than 150 million inhabitants of endemic tropical and subtropical countries are infected and may ... -
Targeted Fast Radio Burst Searches with the Efflesberg 100-m Radio Telescope
(2021-03-24)Fast radio bursts (FRBs) are bright, energetic, millisecond duration radio bursts of extragalactic origin. The source of FRBs still remains an open problem. Since the discovery of FRBs in 2007, over 100 FRBs have been ... -
Targeted therapeutics against cancer and infections Identification and characterization of human ecto-nucleotidase (CD39) and coronaviral protease (Mpro) inhibitors
(2022-09-28)The main objectives of this thesis were the development, characterization and optimization of enzyme inhibitors (i) for the human ecto-nucleotidase CD39, and (ii) for the main protease of the human-pathogenic coronavirus ... -
Targeted transport of active pharmaceutical ingredients into adipose tissue
(2023-02-21)(noch nicht zugänglich / not yet accessible) -
Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy
(2022-07-07)Memory deficits are one of the most debilitating and common symptoms of temporal lobe epilepsy. However, so far, little is known about mechanisms underlying cognitive deficits and how pharmacologically target them. In most ... -
Targeting cholesterol crystals in atherosclerosis with cholesterol solubilizing 2-hydroxypropyl-β-cyclodextrin
(2016-12-21)Atherosclerosis is the underlying pathology of cardiovascular diseases (CVDs), the leading cause of deaths worldwide. Elevated blood cholesterol levels have been linked to this slowly progressing inflammatory disease and ... -
Targeting nucleic acid receptors to improve filarial vaccination in the Litomosoides sigmodontis model
(2022-10-27)Lymphatic filariasis and onchocerciasis (river blindness) are human filarial diseases, which put a high socio-economic burden on endemic countries. Until now no vaccination is available, which could greatly aid elimination ... -
Targeting the Final Step of Blood Coagulation: Structure-Activity-Relationship Studies on the Factor XIIIa Inhibitor Tridegin
(2015-09-23)The prophylaxis and therapy of thrombotic diseases is one of the major columns supporting our continuously increasing life expectancy and health. The transglutaminase factor XIIIa (FXIIIa), which is part of the blood ... -
Tau lepton reconstruction with energy flow and the search for R-parity violating supersymmetry at the ATLAS experiment
(2012-08-31)The ATLAS experiment at the Large Hadron Collider (LHC) is measuring proton-proton collisions at a centre-of-mass energy of √s=7 TeV since 2010, an energy never reached before in collider experiments. A wide variety of ... -
Taxonomy and distributional pattern of Pimplinae (Hymenoptera: Ichneumonidae) from Vietnam
(2013-05-13)This monographic study of Vietnamese Pimplinae is based on several recent publications of the author that are integrated herein to a complete review.<br /> Although Vietnam is one of the global biodiversity hotspots, the ... -
Taxonomy and ecology of amphibian communities in Southern Vietnam: Linking morphology and bioacoustics
(2014-01-16)The Langbian Plateau is known as the southernmost extension of the Truong Son Range (or Annamite Mountains) in southern Vietnam. This area is the type locality of many amphibian species: six species described by Smith ... -
Taxonomy, Phylogeny, and Biogeography of the Andean Hummingbird Genera Coeligena LESSON, 1832; Pterophanes GOULD, 1849; Ensifera LESSON 1843; and Patagona GRAY, 1840 (Aves: Trochiliformes)
(2003)In this study the taxonomy, phylogeny, and biogeography of the Andean hummingbird genera <i>Coeligena</i> Lesson, 1832, <i>Pterophanes</i> Gould, 1849, <i>Ensifera</i> Lesson, 1843, and <i>Patagona</i> Gray, 1840 is analysed ... -
Taxonomy, Phylogeny, and Biogeography of the Hummingbird Genus Thalurania GOULD, 1848 (Aves: Trochilidae)
(2003)A taxonomic revision of the genus Thalurania was carried out based on plumage coloration and morphometric data. Variance in these data was assessed across the whole range of each species. A new methodology of plumage ... -
Tectono-sedimentary Evolution of the NE German Variscan Foreland Basin
(2005)The present study focuses on the tectono-sedimentary evolution of the NE German Variscan foreland basin that is genetically part of the Mid-European Variscides. Within these Mid-European Variscides, the situation considering ...
