E-Dissertationen: Auflistung E-Dissertationen nach Titel
Anzeige der Dokumente 350-369 von 4168
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Bildungsmechanismus und physiologische Relevanz supramolekularer Proteincluster des Amyloid Precursor Protein APP in der Zellmembran
(2013-01-09)Proteine in biologischen Membranen sind in der Regel heterogen in Domänen organisiert. Die Mechanismen dieser Segregation in Membranproteincluster unterschiedlicher Zusammensetzung sind noch immer unverstanden. <br /> Auch ... -
Binary star population synthesis: Progenitors of gravitational wave driven mergers
(2018-06-13)The vast majority of all massive stars are born in binaries. The binarity of a star may influence its life drastically via a large variety of interactions with its companion star. Several astrophysical events, like the ... -
The Binding Behavior of Daptomycin on the Bacterial Membranes
(2018-07-24)Daptomycin (DAP) is a cyclic anionic lipopeptide antibiotic that kills gram-positive bacteria via cell membrane distortion. It is currently approved for treatment of complicated infections caused by gram-positive bacteria, ... -
Binding of cytohesin 2 to the plasma membrane and its relationship with the EGFR
(2018-11-06)Eukaryotic cells are compartmentalized by lipid membranes to achieve the spatial separation of biological processes and signaling pathways. Controlled trafficking of proteins between these compartments as well as the ... -
Bindung, Funktion und Signalwegbevorzugung von orthosterischen, allosterischen und Hybridliganden vermittelt durch Wildtyp und punktmutierte muskarinische hM1-hM5-Rezeptoren
(2021-12-16)Bislang war ungeklärt, ob der Arzneistoff Methantheliniumbromid (MB) (Vagantin®) mit muskarinischen Acetylcholinrezeptoren (<em>h</em>M-Rezeptoren) interagiert (Teilprojekt 1). In umfassenden Untersuchungen konnte erstmalig ... -
Bindungstopografie allosterisch/orthosterischer Hybridagonisten an M2-Acetylcholinrezeptoren
(2008)Muskarinische Acetylcholinrezeptoren besitzen neben der konventionellen, orthosterischen Bindungsstelle für Liganden wie den endogenen Agonisten Acetylcholin oder den Antagonisten N-Methylscopolamin ein weiteres spezifisches ... -
Biochemical and cell culture approach to study the molecular aspects of Metachromatic Leukodystrophy
(2006)Metachromatic leukodystrophy (MLD) is a lysosomal lipid storage disease caused by arylsulfatase A deficiency. In MLD patients, the sphingolipid sulfatide increasingly accumulates leading to progressive demyelination. In ... -
Biochemical and functional analysis of innexin2-containing gap junction channels during organogenesis in Drosophila
(2009-05-13)Gap junctions channels serve as mediators for direct cell-to cell communication between cells of different tissues and organs by the exchange of small metabolites and signalling molecules. They are formed by analogous ... -
Biochemical and genetic analysis of the Sox multienzyme complex in the purple sulfur bacterium Allochromatium vinosum
(2006)The best studied pathway of thiosulfate oxidation is the complete transformation to sulfate by a <i>sox</i> encoded periplasmic multienzyme complex. In the chemotroph <i>Paracoccus pantotrophus</i> Sox proteins are essential ... -
Biochemical and structural characterization of the NLRP3 inflammasome
(2020-02-13)The innate immune system utilizes inflammasome proteins to recognize danger signals and to fight invading pathogens. To date, the most studied inflammasome protein is NLRP3 - a multidomain protein, composed of a N-terminal ... -
Biochemical and Structural Characterization of β-Hydroxylases in Non-Ribosomal Peptide Biosynthesis
(2022-02-02)Hydroxylases are essential in the biosynthesis of natural products by functionalization of building blocks, which derive from primary metabolism. They provide hydrophily for specific interactions or enable further ... -
Biochemical and structural studies of NOD-like receptors and their inhibition by small molecule inhibitors
(2023-03-07)NOD-like receptors (NLRs) are innate immune sensors that can form inflammasomes driving pyroptosis. NLRP3 is the best studied member of the NLRs to date, and its dysregulation has been linked to human diseases relevant to ... -
Biochemical and structural studies of the interaction between ARNO and the Epidermal Growth Factor Receptor
(2014-09-18)Receptor tyrosine kinases (RTKs) and small GTP binding proteins (GTPases) are essential regulators of multiple cellular processes, making a tight control of their activity crucial for cellular homeostasis. Recently, it was ... -
Biochemical characterization of the human Cyclin-dependent kinases Cdk7 and Cdk10
(2021-08-13)Protein kinases comprise a large superfamily of enzymes regulating a plethora of cellular processes. Dysregulation of protein kinases, such as loss of activity, hyperactivity or mislocalisation, is often accompanied with ... -
Biochemical characterization, regulation, and inhibition of human transcription kinases CDK12 and CDK13 and human cell cycle-related kinase CDK14
(2019-11-27)The transcription process is the first step in the molecular information flow from genome to proteome. In eukaryotes, the RNA polymerase II (RNAPII) transcribes genes that code for proteins by synthesizing pre-mature ... -
Biochemical, biophysical and functional analysis of the DsrMKJOP transmembrane complex from Allochromatium vinosum
(2010-12-21)In the present study the DsrMKJOP transmembrane complex was investigated and characterized by biochemical, biophysical and functional analyses. Each of the proteins was successfully produced in <i>E. coli</i> as recombinant ... -
Biochemische Analyse der Interaktion von P2X4 und P2X7 und Charakterisierung von P2X7B und genetisch verlinkten P2X4/P2X7-Konkatameren
(2023-02-23)Das übergeordnete Ziel meiner Arbeit war die Untersuchung der Interaktion von P2X7 und P2X4. Zur Identifikation von potenziellen Interaktionspartnern habe ich den P2X7-Rezeptors von Mensch und Ratten mit den weiteren ... -
Biochemische und funktionale Charakterisierung der Cytohesin-1-Interaktionspartner CYTIP und GRASP
(2006)Das Integrin LFA-1 ist essentiell für die Adhäsion und Migration der Leukozyten. Cytohesin-1 ist ein direkter Interaktionspartner und positiver Regulator des Integrins LFA-1 und katalysiert den Guaninnukleotid-Austausch ... -
Biochemische und genetische Analyse der Wechselwirkung von Rhodococcus equi mit Makrophagen
(2007)<i>Rhodococcus equi</i> ist ein Gram-positives, fakultativ intrazelluläres Bakterium, das in Fohlen unter anderem granulomatöse Bronchopneumonie verursacht. <i>R. equi</i> vermehrt sich in Makrophagen und ist zytotoxisch ... -
Biochemische und molekularbiologische Untersuchungen zur Funktion von DsrN und DsrL im dissimilatorischen Schwefelstoffwechsel von Allochromatium vinosum
(2005)Die im <i>dsr</i>-Operon kodierten Proteine des phototrophen Schwefelbakteriums <i>Allochromatium vinosum</i> sind in die Oxidation akkumulierten Schwefels involviert. Zwei dieser Proteine, DsrN und DsrL, wurden in dieser ...
