E-Dissertationen: Search
Now showing items 611-620 of 632
Elucidating the Role of Long Noncoding RNA H19 in Aortic Valve Disease
(2024-02-02)
(noch nicht zugänglich / not yet accessible)
The chromatin organizer Satb1 regulates the differentiation into CD4+ TH subsets and is essential for the development of TH17 cells
(2021-06-04)
CD4+ T cells play a critical role in host defense and tissue homeostasis. Upon encountering their specific antigen, naive CD4+ T cells can differentiate into the effector T helper (TH) subsets ...
In vivo Relevant Drug Product Evaluation by Using the Biphasic Dissolution Assay (BiPHa+)
(2022-06-13)
An increasing number of new chemical entities struggled with a very poor solubility in aqueous media. Solubility or the ability to dissolve in intestinal media is obligatory for oral bioavailability. Dealing with this ......
Modulation der Expression und Funktion kardialer Gap Junction Kanäle
(2024-02-09)
Die elektrische Kopplung von Kardiomyozyten (KMs) im Herzen wird durch Connexine (Cx) vermittelt. Diese stellen durch die Bildung von Gap Junctions (GJs) Zell-Zell-Kontakte zwischen benachbarten KMs her. Im Herzmuskel ist ......
X-Ray Crystallography of G Protein-coupled Receptors: Exploring Interactions with Drug Molecules
(2023-01-19)
(noch nicht zugänglich / not yet accessible)
Functional characterization of Gαi/s proteins and modulation of their activity by linear and cyclic peptides
(2024-01-30)
Heterotrimeric Gαβγ (guanine nucleotide-binding) proteins serve as molecular switches to activate (“switch on”) or inactivate (“switch off”) diverse intracellular signaling cascades in response to stimulated G protein-coupled ...
Das Cyclodepsipeptid FR900359: Ein Insektizid mit neuem Wirkmechanismus aus Cand. Burkholderia crenata und Chromobacterium vaccinii
(2024-01-16)
Sekundärmetabolite (SM) sind für ihr breites Spektrum an Bioaktivitäten bekannt und daher eine wichtige Quelle für neue Arzneimittelkandidaten. Neben ihrer Relevanz für die Therapie von Erkrankungen sind SM und ihre ......
The cyclic depsipeptide FR900359: An insecticide with a novel mode of action from Cand. Burkholderia crenata and Chromobacterium vaccinii
Secondary metabolites (SM) are known for their broad spectrum ......
The cyclic depsipeptide FR900359: An insecticide with a novel mode of action from Cand. Burkholderia crenata and Chromobacterium vaccinii
Secondary metabolites (SM) are known for their broad spectrum ......
Pulsar Scintillation and Interstellar Lenses
(2024-01-29)
The radio emission of pulsars is scattered within the interstellar medium due to variations of the electron column density. Pulsars are very compact sources of pulsed radiation and, thus, emit spatially coherent radiation ...
Impact of Plant Secondary Metabolites on the Soil Microbiota
(2022-08-26)
This study revealed the impact of 2-benzoxazolinone (BOA), gramine, and quercetin on the microbiota in the bulk soil (Cologne agricultural soil) and investigated direct interactions of the plant secondary metabolites and ...
Analysis of the physiological response of perivascular adipose tissue during cold exposure
(2023-02-22)
Aortic valve disease (AVD) is common for people over 65 and its severity increases with age. Aortic aneurysm (AA) is the tenth cause of death for men above 55. Its prevalence was estimated to be up to 8.9% for men and up ...