E-Dissertationen: Suche
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Distribution and genetic composition of carbapenem-resistance determinants in clinical Acinetobacter isolates – focus on carbapenem-hydrolysing β-lactamases
(2015-02-11)
Acinetobacter baumannii is of global concern in health-care facilities as it can easily thrive in the hospital environment and infections can be difficult to treat. Widespread multi-drug (MDR) resistance and a ...
Synthesis of ganglioside and lysoganglioside lipoforms as internal standards for MS quantification
(2015-01-08)
The goal of this work was to establish methods for the synthesis of modified gangliosides that are suitable as internal standards for mass spectrometry. Quantification of gangliosides is usually achieved by staining after ...
Biosynthesis of soluble capsule precursors in Staphylococcus aureus
(2016-11-28)
Most invasive pathogens produce polysaccharide capsules, which play an essential role in conferring protection against host immune defense. In the case of Staphylococcus aureus, most clinical isolates are encapsulated, and ......
Chelation as a strategy with the potential to overcome multidrug resistance in cancer
(2016-09-02)
According to the World Health Organisation cancer is the second leading cause of death in industrialized countries. In many cases treatment fails due to the development of resistance against multiple (structurally and ...
Chemisch-molekularbiologische Studien zu Pyransynthase-Domänen in trans-AT-Polyketidsynthasen
(2016-07-21)
Im Rahmen dieser Promotionsarbeit wurde die postulierte katalytische Aktivität von Pyransynthase-Domänen (PS-Domänen) verschiedener trans-Acyltransferase-Polyketidsynthasen (trans-AT-PKS) in vitro ...
Synthesis and Characterisation of wALAD Inhibitors and Novel ABAL Probes
(2016-10-12)
The here presented work comprises two projects with highly interdisciplinary topics in the chemical biology field. The development of novel small molecule ALAD inhibitors which might show their potential as novel antifilarial, ...
Click-SELEX: A versatile approach towards nucleobase-modified aptamers
(2016-11-28)
Aptamers are short nucleic acids that can be selected to bind specifically and with high affinity to a variety of targets, including small organic molecules and proteins. However, for a multitude of targets, traditional ...
Neuroinflammation in Mausmodellen der Metachromatischen Leukodystrophie
(2016-10-18)
Arylsulfatase A (ASA) katalysiert die Desulfatierung von 3-O-Sulfogalaktosylceramid (Sulfatid), einem Hauptbestandteil der Myelinscheide. Ein Verlust der Aktivität von ASA führt zu der lysosomalen Speichererkrankung ...
Oxytocin – the prosocial molecule?: Intranasal oxytocin effects on social approach behavior, social cognition, volitional and emotional ambivalence in healthy human beings
(2015-10-30)
Oxytocin (OXT) is a highly conserved neuropeptide, regarding both its chemical structure and its functionality. It has been traced back at least 700 million years. OXT’s fundamental role lies in reproduction and parenting ...
Proteomische Funktionsanalyse humanbiologischer Systeme mittels chemisch modifizierter Proteine
(2016-04-18)
Das humane Proteom unterliegt gegenüber dem eher statischen Genom einem kontinuierlichen Auf- und Abbau. Diese Dynamik zeigt sich durch ein mehrschichtiges Muster an Protein-Protein Interaktionen.
Im ersten Teil ...
Im ersten Teil ...