E-Dissertationen: Suche
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Connectomic Analysis of a Peptidergic Circuit in Drosophila
(2017-09-21)
The homologous neuropeptides neuromedinU (NMU) and hugin have similar effects on food intake and physical activity in mammals and Drosophila, respectively. Little is known about the neuronal networks that employ either ......
Die homologen Neuropeptide NeuromedinU (NMU) und Hugin haben ähnliche Effekte auf Nahrungsaufnahme und physische Aktivität in Säugetieren bzw. Drosophila. Über die neuralen Netzwerke, in denen das jeweilige Neuropeptid ......
Die homologen Neuropeptide NeuromedinU (NMU) und Hugin haben ähnliche Effekte auf Nahrungsaufnahme und physische Aktivität in Säugetieren bzw. Drosophila. Über die neuralen Netzwerke, in denen das jeweilige Neuropeptid ......
Identification, optimization and characterization of pharmacological tools for the cannabinoidactivated orphan G protein-coupled receptor GPR18 and related receptors
(2017-12-21)
Cannabinoid receptors comprise two classical subtypes, CB1 and CB2, which belong to the large family of G protein-coupled receptors (GPCRs). They are the major targets of cannabinoids such as ......
Hippocampal cellular and network properties in a mouse model of metachromatic leukodystrophy
(2017-11-30)
The human disease of metachromatic leukodystrophy (MLD) is caused by a single or multiple allelic mutations within the gene locus of arylsulfatase A (ASA). This protein is a lysosomal enzyme catalyzing the degradation of ...
Purines and 9-deazapurines as Modulators of Multidrug Resistance-associated Protein 1 (MRP1/ABCC1)-mediated Transport
(2017-11-14)
Expression of ABC-transport proteins is a major obstacle in cancer chemotherapy. Especially MRP1, P-gp and BCRP are expressed in different malignancies like lung cancer, colon carcinomas, leukemias, bladder cancer, myeloma, ...
Identifizierung und Charakterisierung neuer Biomarker für maligne Tumorerkrankungen
(2017-12-11)
Die Therapieoptionen sowohl im Prostatakarzinom als auch in Tumoren des Kopf- und Halsbereichs sind limitiert und die Stratifizierung der Patienten in unterschiedliche Risiko- oder Therapiegruppen muss weiter verbessert ......
Influence of the Conformation of Conotoxins on their Bioactivity
(2017-12-14)
In the last decade peptides filled the gap between small molecule drugs and biologics as therapeutics. A rich source of such peptides represents the venom of different animals evolved over millions of years. Conotoxins are ...
MicroRNA vermittelte Regulation der Expression von Mtss1 während der Entwicklung des Kleinhirns der Maus
(2017-11-14)
Die Entwicklung und Differenzierung des Cerebellums ist von einer regelgerechten Neuritogenese verschiedener Zelltypen abhängig. Dies erfordert eine ständige Umgestaltung des Zytoskeletts und eine Regulation der Zellform. ...
Mosquitoes and Maladies among Men using Marshes: Is the Contraction of Diseases in Wetlands a Question of Use?
(2017-11-09)
In environments where water is scarce, as is the case in semiarid areas in rural East Africa, fragile wetland ecosystems are increasingly being tapped in order to combat food insecurity and to provide important life-support ...
Rapid astrocyte morphology changes during epileptogenesis in the rodent hippocampus
(2017-05-15)
In the past decades astrocytes have been demonstrated to play an important role in physiological brain processes but also neurodegenrative diseases. Their characteristic morphology allows them to closely contact neurons. ...
Unravelling mechanisms causing astrocytic uncoupling in epilepsy
(2017-10-06)
The dynamic regulation of connexins throughout its life cycle has profound impact on the level of gap junctional coupling in astrocytes. Astrocytic uncoupling in epilepsy can be viewed in the context of modifications in ...