E-Dissertationen: Suche
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Network effects of eslicarbazepine in the hippocampus
(2020-05-18)
Nearly 50 million people worldwide suffer from epilepsy, with 1/3 of the patients remaining without seizure control. This high number emphasizes the importance to develop new anti-epileptic drugs (AEDs) and to understand ...
Characterization of polygalacturonase inhibitor 1-like protein (CpPGIP) from Craterostigma plantagineum and analysis of stress inducible pcC13-62 promoters to understand desiccation tolerance in Linderniaceae
(2020-09-02)
The work is divided into two major parts. The first part is the characterization of an important cell wall protein “polygalacturonase inhibitor 1-like protein (CpPGIP)” and in the second part we studied “stress inducible ......
Comparative analysis of the insect mobile genetic element repertoire and its influence on genome size dynamics
(2020-06-10)
This thesis presents comparative genomics studies in insects as well as bioinformatics software development. Its empirical research part is focused mainly on mobile genetic elements, also termed transposable elements. The ......
In Silico Facets of Biochemical Research: Accounts from Protein Folding and Protein-Ligand Interaction Studies
(2020-09-04)
Exponential advancements in computer technology over the last five decades have ubiquitously benefited science and humanity as a whole. Consequent beneficiaries of this surge of computational power include all subfields ......
Control of ion and neurotransmitter homeostasis by hippocampal astroglial networks
(2020-12-16)
The present study addressed the contribution of astrocytic gap junction channels to extracellular K+ clearance. Astrocyte form large networks through gap junction coupling that enables intercellular communication ...
The influence of environmental UVB radiation on growth, immunity, behavior and sexually selected traits in the three-spined stickleback (Gasterosteus aculeatus)
(2020-07-13)
Changing photic conditions are, next to global warming, the major aspect in terms of ongoing global climate change and mainly occur within the short-wave and high-energetic ultraviolet-B (UVB) part of the electromagnetic ...
Analyse des Lon Einflusses auf die Hitze-induzierte Aggregation mitochondrialer Proteine und auf die Bildung von Aggregatablagerungen
(2020-07-13)
Die mitochondriale Matrix Protease Lon ist ein essentieller Bestandteil des mitochondrialen Protein Qualitätskontroll-Systems. Der Verlust von Lon führt zu einer erhöhten Apoptoserate und embryonaler Letalität im Mausmodell. ...
Functional analysis of the endocannabinoid system in conditional mouse mutants
(2020-09-04)
In the scope of this thesis conditional knockout mice with a cell-specific deletion of Dagla (diacylglycerol lipase alpha) in neurons, astrocytes or microglia cells were generated, in order to identify the cellular source ...
Aufklärung des zentralen Kohlenstoff- und Energiemetabolismus des Darmbakteriums Prevotella copri
(2020-06-19)
Die vorliegende Arbeit befasste sich mit dem zentralen Kohlenstoff- und Energiemetabolismus von Prevotella (P.) copri, eines der relevantesten Bakterien der menschlichen Darmflora. Um zu verstehen, wie die Prädominanz ......
State-dependent processing of Dentate Gyrus granule cell activity in-vivo
(2020-12-16)
The ability to form dissimilar neural activity patterns from similar sensory driven inputs is a phenomenon found in all vertebrates, called pattern separation. In mammals, pattern separation is closely related to a subregion ...