E-Dissertationen: Search
Now showing items 11-20 of 23
N-glycosylation of intrinsic and engineered N-X-S/T motifs by Pichia pastoris can be exploited to ligate the mannose receptor but reveals no gain in immunogenicity per se
(2016-12-22)
Vaccination has the power to eradicate viral diseases and is a promising approach to cure cancer. However, modern vaccination strategies repeatedly fail in inducing a robust cytotoxic CD8+ T cell response, which ...
Study on the role of Cofilin 2 in the brain
(2016-12-22)
Three actin depolymerization factors are expressed in the brain, named Cofilin 1 (non-muscle Cofilin), ADF and Cofilin 2, which was long declared as muscle-specific isoform. All three members share similar biochemical ...
Functional characterization of Cytoplasmic Polyadenylation Element Binding proteins in the developing and diseased brain
(2016-12-22)
Gliomas are the most common primary brain tumors with aggressive progression and devastating prognosis. Therefore identification of new therapeutic and diagnostic factors is necessary to improve the dramatic situation of ...
Click-SELEX: A versatile approach towards nucleobase-modified aptamers
(2016-11-28)
Aptamers are short nucleic acids that can be selected to bind specifically and with high affinity to a variety of targets, including small organic molecules and proteins. However, for a multitude of targets, traditional ...
Identification of protective immune responses and the immunomodulatory capacity of Litomosoides sigmodontis
(2016-11-29)
Using the mouse model Litomosoides sigmodontis, research focusing on the protective immune responses within the host as well as the immunomodulatory capabilities of filarial infections is possible. The immunomodulatory ......
Structural and Functional Characterization of Neurotoxic Oligomers of Pro-aggregant Tau Repeat Domain: A model for Tauopathy disease
(2016-04-26)
Tau protein is a microtubule associated protein present abundantly in the neurons of the central nervous system where it stabilizes the axonal microtubules thereby providing structural architecture for the axons of neurons. ...
Entwicklung neuer Therapiekonzepte im myxoiden Liposarkom: Die Rolle von Fibroblastenwachstumsfaktor-Rezeptoren und microRNAs
(2016-04-21)
Myxoide Liposarkome gehören zu den häufigsten Weichgewebssarkomen. Ihre Pathogenese ist aber bislang nur unvollständig verstanden und es stehen keine zielgerichteten Therapien zur Verfügung. Die für myxoide Liposarkome ...
Proteomische Funktionsanalyse humanbiologischer Systeme mittels chemisch modifizierter Proteine
(2016-04-18)
Das humane Proteom unterliegt gegenüber dem eher statischen Genom einem kontinuierlichen Auf- und Abbau. Diese Dynamik zeigt sich durch ein mehrschichtiges Muster an Protein-Protein Interaktionen.
Im ersten Teil ...
Im ersten Teil ...
The role of the Hippo pathway in etiology and progression of pancreato-biliary tumors and clear cell renal cell carcinoma
(2016-01-21)
In the quest for the discovery of novel targets for cancer therapy, aberrantly reactivated embryonic signaling pathways have proven to be a rich mine and recent years have seen the introduction of the hedgehog-inhibitor ...
Neuroprotective Effects of Polysialic Acid and SIGLEC-11 in Activated Phagocytic Cells
(2016-03-30)
SIGLEC-11 is an inhibitory receptor expressed on microglial cells and macrophages and can recognize α 2→8 linked Sias structures. The surface of neuron is decorated by different lengths of polySias. PolySia-SIGLEC-11 ...