E-Dissertationen: Search
Now showing items 3631-3640 of 4075
Discovering lesser known molecular players and mechanistic patterns in Alzheimer's disease using an integrative disease modelling approach
(2018-12-13)
Convergence of exponentially advancing technologies is driving medical research with life changing discoveries. On the contrary, repeated failures of high-profile drugs to battle Alzheimer's disease (AD) has made it one ...
The role of the transcription factor BCL11A in midbrain dopaminergic neurons
(2022-03-11)
Midbrain dopaminergic (mDA) neurons are located in three midbrain nuclei, the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field (RRF). mDA neurons are diverse in their developmental origin, their ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
Analysis of inclusive semileptonic B meson decays with τ lepton final states at the Belle experiment
(2018-06-15)
In this thesis, the measurement of the inclusive branching fraction of B→Xτν decays at the Belle experiment is presented. Previous measurements of the inclusive semileptonic b-hadron branching fraction BR(b→Xτν) in ...
The Impact of CD44 and Osteopontin on Hematopoiesis
(2021-10-25)
Hematopoiesis is the process, which enables the replenishment of blood cellular components in mammals throughout their lifespan. Hematopoietic stem cells (HSC), which reside within the bone marrow (BM), are the primary ...
Electrostatic anchoring of SNAP25 to the plasma membrane
(2021-07-21)
Neurotransmission is based on incredibly rapid membrane trafficking cycles, mediating the release of neurotransmitters. The fusion machinery of the well-studied SNARE protein complex ensures the speed and precision of ...
Validierung und forensische Anwendung chromatographisch-massenspektrometrischer Methoden zum Nachweis von klassischen illegalen Drogen, neuen psychoaktiven Substanzen und Arzneistoffen in verschiedenen Matrices am Beispiel von Heroin, Cathinon-Derivaten und Propofol
(2018-06-12)
Im Rahmen der forensisch-toxikologischen Begutachtung sind neben den klassischen illegalen Drogen auch diverse Medikamente sowie neue psychoaktive Substanzen von Relevanz. Für den gerichtsverwertbaren Nachweis dieser ...
Schrumpfungsprozesse als zentrale Herausforderung für die zukünftige Entwicklung von Kommunen im Rahmen der rheinland-pfälzischen Dorferneuerung: dargestellt am Fallbeispiel des Landkreises Mayen-Koblenz
(2021-03-23)
Die Herausforderungen und bislang zumeist unbekannten Änderungserfordernisse an bestehende Strukturen, welche sich aus den ablaufenden Prozessen des demographischen Wandels ergeben, sind die momentan gewichtigsten, welche ...
Modulation der Signaltransduktion des muskarinischen M1-Rezeptors mittels orthosterischer und dualsterischer Liganden
(2018-09-26)
Muskarinische Acetylcholin Rezeptoren (mAChRs) gehören zur Superfamilie der G Protein-gekoppelten Rezeptoren (GPCRs). Der Subtyp 1 der mAChRs (M1-mAChR) koppelt bevorzugt an G Proteine der Gq-Familie, kann jedoch promiskuitiv ...
The reproductive biology of Cretaceous oviraptorid dinosaurs and its implication for the origin of bird reproduction
(2018-11-13)
This dissertation aims to pioneer an integrative approach that includes all lines of evidence to comprehensively and in detail reconstruct the biology of an extinct animal. Specifically, the dissertation consists of several ...
Animal-Robot Interactions: Electrocommunication, Sensory Ecology, and Group Dynamics in a Mormyrid Weakly Electric Fish
(2018-12-12)
Mormyrid weakly electric fish possess a specialized electrosensory system. During the process of active electrolocation, these animals perceive self-generated electric organ dis-charges (EOD) and are thereby able to detect ...