E-Dissertationen: Search
Now showing items 441-450 of 627
Über ABCG2-Inhibitoren mit Heteroaryl-phenylamid- und Carborancarboxamid-Grundstruktur
(2017-05-17)
Der Ansatz, die Multidrug-Resistenz eines Tumors über einen Modulator bzw. Inhibitor aufzuheben, wurde in dieser Arbeit mit der Darstellung potenter, selektiver und untoxischer Hemmstoffe für den Transporter ABCG2 verfolgt ...
Atmospheric Downscaling using Multi-Objective Genetic Programming
(2017-10-10)
Numerical models are used to simulate and to understand the interplay of physical processes in the atmosphere, and to generate weather predictions and climate projections. However, due to the high computational cost of ...
Suitability Analysis of Satellite Remote Sensing Methods to Map Agricultural Land Use Change after Zimbabwe's "Fast Track Land Reform Programme"
(2017-04-06)
Forced evictions of white commercial farmers in the year 2000 took the Zimbabwean land reform programme to a new level. While international media covered the tragedies of white farmers, the collapse of a state economy and ...
Enzyme-inhibitory secondary metabolites and their exudation in the marine-derived fungus Epicoccum nigrum link
(2017-04-25)
The kingdom of fungi harbors a huge diversity of life forms. The Ascomycota in particular are a prolific source of medicinal drugs and new lead structures with potent bioactivities. During this work, two marine-derived ......
The mannose receptor influences antigen-presenting cells by direct interaction with CD45R0
(2017-05-15)
The immune system has to manage the critical decision to induce either immunity or tolerance. Cells that take part in the regulatory processes of the immune system are amongst others antigen presenting cells (APCs), ...
Vergleichende Untersuchung der Genexpression in humanen Tumorzellknoten und Tumorzellrasen in vitro
(2017-03-24)
Während der Arzneimittelentwicklung scheitern viele in vitro vielversprechend scheinende Wirkstoffe während der klinischen Prüfung am humanen Patienten. Für onkologische Wirkstoffe ist die Ausfallquote besonders hoch. Aus ......
The importance of endogenous cannabinoids in stress-related disorders and depression
(2017-02-03)
The endogenous cannabinoid system (ECS) is a unique neuromodulatory system, essentially involved in a variety of physiological processes. It consists of the two major endogenous cannabinoids (eCBs), anandamide and 2-AG, ......
Role of IgG4-mediated Suppression of Immune Effector Mechanisms in Human Filariasis
(2017-03-15)
Lymphatic filariasis (LF) is a major public health concern in tropical and subtropical countries. The infection affects more than 120 million people and has significant social and economic consequences on affected individuals ......
Biological Evaluation of Serine Protease Inhibitors and Inducers of Protein Degradation
(2020-10-02)
Serine proteases represent the largest group of enzymes of the human degradome. As such, they are valuable targets for the development of new drugs, due to their involvement in several diseases. Over the course of this ...
Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
(2020-02-07)
The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a ......